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Effectiveness and tolerance of single tablet versus once daily multiple tablet regimens as first-line antiretroviral therapy - Results from a large french multicenter cohort study

Author

Listed:
  • Laurent Cotte
  • Tristan Ferry
  • Pascal Pugliese
  • Marc-Antoine Valantin
  • Clotilde Allavena
  • André Cabié
  • Isabelle Poizot-Martin
  • David Rey
  • Claudine Duvivier
  • Antoine Cheret
  • Pierre Dellamonica
  • Pierre Pradat
  • Jean-Jacques Parienti
  • Dat’AIDS study group

Abstract

Objectives: Pill burden during antiretroviral treatment (ART) is associated with worse adherence and impaired virological suppression. We compared the effectiveness, tolerance, and persistence on treatment of single tablet regimens (STRs) with non-STR once-daily regimens in patients receiving first-line ART. Methods: Retrospective analysis of naïve HIV-1 infected patients prospectively enrolled in the French Dat’AIDS cohort and initiating first-line ART with STRs or once-daily non-STRs from 2004 to 2013. The primary outcome was time to treatment discontinuation defined by any change in the treatment regimen. STR and non-STR groups were compared controlling for baseline risk factors by inverse probability weighted treatment Cox analysis (IPWT) and propensity-score matching (PSM). Results: Overall, 3212 patients (STR 499, non-STR 2713) were included. Median time to treatment discontinuation was shorter in non-STR patients than in STR patients, both in the IPWT (HR = 0.61, p

Suggested Citation

  • Laurent Cotte & Tristan Ferry & Pascal Pugliese & Marc-Antoine Valantin & Clotilde Allavena & André Cabié & Isabelle Poizot-Martin & David Rey & Claudine Duvivier & Antoine Cheret & Pierre Dellamonica, 2017. "Effectiveness and tolerance of single tablet versus once daily multiple tablet regimens as first-line antiretroviral therapy - Results from a large french multicenter cohort study," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-12, February.
    • Handle: RePEc:plo:pone00:0170661
    DOI: 10.1371/journal.pone.0170661
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    References listed on IDEAS

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    1. Paul E Sax & Juliana L Meyers & Michael Mugavero & Keith L Davis, 2012. "Adherence to Antiretroviral Treatment and Correlation with Risk of Hospitalization among Commercially Insured HIV Patients in the United States," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-10, February.
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    Cited by:

    1. Hiroyuki Tanaka & Toshihisa Onoda & Toshihiro Ishii, 2022. "Understanding the Actual Use of Anti-HIV Drugs in Japan from 2016 to 2019: Demonstrating Epidemiological Relevance of NDB Open Data Japan for Understanding Japanese Medical Care," IJERPH, MDPI, vol. 19(19), pages 1-11, September.
    2. Sophie Degroote & Linos Vandekerckhove & Dirk Vogelaers & Charlotte Vanden Bulcke, 2022. "Patient-reported outcomes among people living with HIV on single- versus multi-tablet regimens: Data from a real-life setting," PLOS ONE, Public Library of Science, vol. 17(1), pages 1-15, January.

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