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Prognostic role of the prognostic nutritional index (PNI) in patients with head and neck neoplasms undergoing radiotherapy: A meta-analysis

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  • Yujie Shi
  • Yue Zhang
  • Yaling Niu
  • Yingjie Chen
  • Changgui Kou

Abstract

Background: This novel meta-analysis was conducted to systematically and comprehensively evaluate the prognostic role of the pretreatment PNI in patients with head and neck neoplasms (HNNs) undergoing radiotherapy. Methods: Three databases, PubMed, Embase, and Web of Science, were used to retrieve desired literature. Hazard ratios (HRs) with 95% confidence intervals (CIs) were extracted and pooled by fixed-effects or random-effects models to analyze the relationship between the PNI and survival outcomes: overall survival (OS), distant metastasis-free survival (DMFS), and progression-free survival (PFS). Results: Ten eligible studies involving 3,458 HNN patients were included in our analysis. The robustness of the pooled results was ensured by heterogeneity tests (I2 = 22.6%, 0.0%, and 0.0% for OS, DMFS, and PFS, respectively). The fixed-effects model revealed a lower pretreatment PNI was significantly related to a worse OS (HR = 1.974; 95% CI: 1.642–2.373; P

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  • Yujie Shi & Yue Zhang & Yaling Niu & Yingjie Chen & Changgui Kou, 2021. "Prognostic role of the prognostic nutritional index (PNI) in patients with head and neck neoplasms undergoing radiotherapy: A meta-analysis," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0257425
    DOI: 10.1371/journal.pone.0257425
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    1. Steven A. Rosenberg, 2001. "Progress in human tumour immunology and immunotherapy," Nature, Nature, vol. 411(6835), pages 380-384, May.
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