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Progress in human tumour immunology and immunotherapy

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  • Steven A. Rosenberg

    (National Cancer Institute, Building 10, Room 2B42)

Abstract

Studies of the administration of interleukin-2 to patients with metastatic melanoma or kidney cancer have shown that immunological manipulations can mediate the durable regression of metastatic cancer. The molecular identification of cancer antigens has opened new possibilities for the development of effective immunotherapies for patients with cancer. Clinical studies using immunization with peptides derived from cancer antigens have shown that high levels of lymphocytes with anti-tumour activity can be raised in cancer-bearing patients. Highly avid anti-tumour lymphocytes can be isolated from immunized patients and grown in vitro for use in cell-transfer therapies. Current studies are aimed at understanding the mechanisms that enable the cancer to escape from immune attack.

Suggested Citation

  • Steven A. Rosenberg, 2001. "Progress in human tumour immunology and immunotherapy," Nature, Nature, vol. 411(6835), pages 380-384, May.
    • Handle: RePEc:nat:nature:v:411:y:2001:i:6835:d:10.1038_35077246
    DOI: 10.1038/35077246
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    Cited by:

    1. Yujie Shi & Yue Zhang & Yaling Niu & Yingjie Chen & Changgui Kou, 2021. "Prognostic role of the prognostic nutritional index (PNI) in patients with head and neck neoplasms undergoing radiotherapy: A meta-analysis," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-13, September.
    2. Xiaobin Gu & Xian-Shu Gao & Shangbin Qin & Xiaoying Li & Xin Qi & Mingwei Ma & Hao Yu & Shaoqian Sun & Dong Zhou & Wen Wang & Wei Xiong, 2016. "Elevated Platelet to Lymphocyte Ratio Is Associated with Poor Survival Outcomes in Patients with Colorectal Cancer," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-14, September.
    3. Yang, Jin & Tang, Sanyi & Cheke, Robert A., 2015. "Modelling pulsed immunotherapy of tumour–immune interaction," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 109(C), pages 92-112.

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