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Risk of adverse events in gastrointestinal endoscopy: Zero-inflated Poisson regression mixture model for count data and multinomial logit model for the type of event

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  • Marco Gemma
  • Fulvia Pennoni
  • Roberta Tritto
  • Massimo Agostoni

Abstract

Background and aims: We analyze the possible predictive variables for Adverse Events (AEs) during sedation for gastrointestinal (GI) endoscopy. Methods: We consider 23,788 GI endoscopies under sedation on adults between 2012 and 2019. A Zero-Inflated Poisson Regression Mixture (ZIPRM) model for count data with concomitant variables is applied, accounting for unobserved heterogeneity and evaluating the risks of multi-drug sedation. A multinomial logit model is also estimated to evaluate cardiovascular, respiratory, hemorrhagic, other AEs and stopping the procedure risk factors. Results: In 7.55% of cases, one or more AEs occurred, most frequently cardiovascular (3.26%) or respiratory (2.77%). Our ZIPRM model identifies one population for non-zero counts. The AE-group reveals that age >75 years yields 46% more AEs than age

Suggested Citation

  • Marco Gemma & Fulvia Pennoni & Roberta Tritto & Massimo Agostoni, 2021. "Risk of adverse events in gastrointestinal endoscopy: Zero-inflated Poisson regression mixture model for count data and multinomial logit model for the type of event," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-16, June.
    • Handle: RePEc:plo:pone00:0253515
    DOI: 10.1371/journal.pone.0253515
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    References listed on IDEAS

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    1. Lim, Hwa Kyung & Li, Wai Keung & Yu, Philip L.H., 2014. "Zero-inflated Poisson regression mixture model," Computational Statistics & Data Analysis, Elsevier, vol. 71(C), pages 151-158.
    2. DeSarbo, W.S. & Wedel, M., 1993. "A Review of Recent Developments in Latent Class Regression Models," Papers 521, Groningen State, Institute of Economic Research-.
    3. Wedel, M, et al, 1993. "A Latent Class Poisson Regression Model for Heterogeneous Count Data," Journal of Applied Econometrics, John Wiley & Sons, Ltd., vol. 8(4), pages 397-411, Oct.-Dec..
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