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Congenital Zika syndrome: A systematic review

Author

Listed:
  • Danielle A Freitas
  • Reinaldo Souza-Santos
  • Liege M A Carvalho
  • Wagner B Barros
  • Luiza M Neves
  • Patrícia Brasil
  • Mayumi D Wakimoto

Abstract

Background: The signs and symptoms of Zika virus infection are usually mild and self-limited. However, the disease has been linked to neurological complications such as Guillain-Barré syndrome and peripheral nerve involvement, and also to abortion and fetal deaths due to vertical transmission, resulting in various congenital malformations in newborns, including microcephaly. This review aimed to describe the o signs and symptoms that characterize the congenital Zika syndrome. Methods and findings: A systematic review was performed with a protocol and described according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The search strategy yielded 2,048 studies. After the exclusion of duplicates and application of inclusion criteria, 46 studies were included. The main signs and symptoms associated with the congenital Zika syndrome were microcephaly, parenchymal or cerebellar calcifications, ventriculomegaly, central nervous system hypoplasia or atrophy, arthrogryposis, ocular findings in the posterior and anterior segments, abnormal visual function and low birthweight for gestational age. Conclusions: Zika virus infection during pregnancy can cause a series of changes in the growth and development of children, while impacting the healthcare system due to the severity of cases. Our findings outline the disease profile in newborns and infants and may contribute to the development and updating of more specific clinical protocols.

Suggested Citation

  • Danielle A Freitas & Reinaldo Souza-Santos & Liege M A Carvalho & Wagner B Barros & Luiza M Neves & Patrícia Brasil & Mayumi D Wakimoto, 2020. "Congenital Zika syndrome: A systematic review," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-27, December.
  • Handle: RePEc:plo:pone00:0242367
    DOI: 10.1371/journal.pone.0242367
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    1. De Barros Miranda-Filho, D. & Martelli, C.M.T. & De Alencar Ximenes, R.A. & Araújo, T.V.B. & Rocha, M.A.W. & Ramos, R.C.F. & Dhalia, R. & De Oliveira Franca, R.F. & De Azevedo Marques Junior, E.T. & R, 2016. "Initial description of the presumed congenital Zika syndrome," American Journal of Public Health, American Public Health Association, vol. 106(4), pages 598-600.
    2. Marcia C. Castro & Qiuyi C. Han & Lucas R. Carvalho & Cesar G. Victora & Giovanny V. A. França, 2018. "Implications of Zika virus and congenital Zika syndrome for the number of live births in Brazil," Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, vol. 115(24), pages 6177-6182, June.
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