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Initial description of the presumed congenital Zika syndrome

Author

Listed:
  • De Barros Miranda-Filho, D.
  • Martelli, C.M.T.
  • De Alencar Ximenes, R.A.
  • Araújo, T.V.B.
  • Rocha, M.A.W.
  • Ramos, R.C.F.
  • Dhalia, R.
  • De Oliveira Franca, R.F.
  • De Azevedo Marques Junior, E.T.
  • Rodrigues, L.C.

Abstract

Objectives. To provide an initial description of the congenital syndrome presumably associated with infection by Zika virus compared with other syndromes including congenital infections of established etiologies. Methods.Weprovide an overview of a published case series of 35 cases, a clinical series of 104 cases, and published and unpublished reports of clinical and laboratory findings describing cases diagnosed since the beginning of the epidemic of microcephaly in Brazil. Results. About60%to70%of mothers report rash during pregnancy; mainly in the first trimester. Principal features are microcephaly, facial disproportionality, cutis girata, hypertonia/spasticity, hyperreflexia, and irritability; abnormal neuroimages include calcifications, ventriculomegaly, and lissencephaly. Hearing and visual abnormalities may be present. Conclusions. Preliminary data suggest that severe congenital abnormalities are linked to Zika virus infection. Cases have severe abnormalities, and although sharing many characteristics with congenital abnormalities associated with other viral infections, abnormalities presumably linked to the Zika virus may have distinguishing characteristics. These severe neurologic abnormalities may result in marked mental retardation and motor disabilities for many surviving offspring. Policy Implications. Affected nations need to prepare to provide complex and costly multidisciplinary care that children diagnosed with this new congenital syndrome will require.

Suggested Citation

  • De Barros Miranda-Filho, D. & Martelli, C.M.T. & De Alencar Ximenes, R.A. & Araújo, T.V.B. & Rocha, M.A.W. & Ramos, R.C.F. & Dhalia, R. & De Oliveira Franca, R.F. & De Azevedo Marques Junior, E.T. & R, 2016. "Initial description of the presumed congenital Zika syndrome," American Journal of Public Health, American Public Health Association, vol. 106(4), pages 598-600.
    • Handle: RePEc:aph:ajpbhl:10.2105/ajph.2016.303115_3
    DOI: 10.2105/AJPH.2016.303115
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    Cited by:

    1. Neal D. E. Alexander & Wayner V. Souza & Laura C. Rodrigues & Cynthia Braga & André Sá & Luciana Caroline Albuquerque Bezerra & Celina Maria Turchi Martelli, 2020. "Spatiotemporal Analysis of the Population Risk of Congenital Microcephaly in Pernambuco State, Brazil," IJERPH, MDPI, vol. 17(3), pages 1-8, January.
    2. Wenham, Clare & Abagaro, Camila & Arévalo, Amaral & Coast, Ernestina & Corrêa, Sonia & Cuéllar, Katherine & Leone, Tiziana & Valongueiro, Sandra, 2021. "Analysing the intersection between health emergencies and abortion during Zika in Brazil, El Salvador and Colombia," Social Science & Medicine, Elsevier, vol. 270(C).
    3. Danielle A Freitas & Reinaldo Souza-Santos & Liege M A Carvalho & Wagner B Barros & Luiza M Neves & Patrícia Brasil & Mayumi D Wakimoto, 2020. "Congenital Zika syndrome: A systematic review," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-27, December.
    4. Jasmine Morgan & Clare Strode & J Enrique Salcedo-Sora, 2021. "Climatic and socio-economic factors supporting the co-circulation of dengue, Zika and chikungunya in three different ecosystems in Colombia," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 15(3), pages 1-29, March.

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