IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0241136.html
   My bibliography  Save this article

Effect of age on the gap-prepulse inhibition of the cortical N1-P2 complex in humans as a step towards an objective measure of tinnitus

Author

Listed:
  • Yunseo Ku
  • Do Youn Kim
  • Chiheon Kwon
  • Tae Soo Noh
  • Moo Kyun Park
  • Jun Ho Lee
  • Seung Ha Oh
  • Hee Chan Kim
  • Myung-Whan Suh

Abstract

The gap-prepulse inhibition of the acoustic startle reflex has been widely used as a behavioral method for tinnitus screening in animal studies. The cortical-evoked potential gap-induced inhibition has also been investigated in animals as well as in human subjects. The present study aimed to investigate the effect of age on the cortical N1-P2 complex in the gap-prepulse inhibition paradigm. Fifty-seven subjects, aged 20 to 68 years, without continuous tinnitus, were tested with two effective gap conditions (embedded gap of 50- or 20-ms duration). Retest sessions were performed within one month. A significant gap-induced inhibition of the N1-P2 complex was found in both gap durations. Age differently affected the inhibition, depending on gap duration. With a 50-ms gap, the inhibition decreased significantly with the increase in age. This age-inhibition relationship was not found when using a 20-ms gap. The results were reproducible in the retest session. Our findings suggest that the interaction between age and gap duration should be considered when applying the gap-induced inhibition of the cortical-evoked potential as an objective measure of tinnitus in human subjects. Further studies with tinnitus patients are warranted to identify gap duration that would minimize the effects of age and maximize the difference in the inhibition between those with and without tinnitus.

Suggested Citation

  • Yunseo Ku & Do Youn Kim & Chiheon Kwon & Tae Soo Noh & Moo Kyun Park & Jun Ho Lee & Seung Ha Oh & Hee Chan Kim & Myung-Whan Suh, 2020. "Effect of age on the gap-prepulse inhibition of the cortical N1-P2 complex in humans as a step towards an objective measure of tinnitus," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-17, November.
    • Handle: RePEc:plo:pone00:0241136
    DOI: 10.1371/journal.pone.0241136
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0241136
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0241136&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0241136?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Navzer D. Engineer & Jonathan R. Riley & Jonathan D. Seale & Will A. Vrana & Jai A. Shetake & Sindhu P. Sudanagunta & Michael S. Borland & Michael P. Kilgard, 2011. "Reversing pathological neural activity using targeted plasticity," Nature, Nature, vol. 470(7332), pages 101-104, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Konstantin Tziridis & Jana Friedrich & Petra Brüeggemann & Birgit Mazurek & Holger Schulze, 2022. "Estimation of Tinnitus-Related Socioeconomic Costs in Germany," IJERPH, MDPI, vol. 19(16), pages 1-17, August.
    2. Michael Boedts & Andreas Buechner & S. Guan Khoo & Welmoed Gjaltema & Frederique Moreels & Anke Lesinski-Schiedat & Philipp Becker & Helen MacMahon & Lieke Vixseboxse & Razieh Taghavi & Hubert H. Lim , 2024. "Combining sound with tongue stimulation for the treatment of tinnitus: a multi-site single-arm controlled pivotal trial," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0241136. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.