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Reversing pathological neural activity using targeted plasticity

Author

Listed:
  • Navzer D. Engineer

    (Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas
    MicroTransponder Inc., 2802 Flintrock Trace, Suite 225, Austin, Texas 78738, USA)

  • Jonathan R. Riley

    (Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas)

  • Jonathan D. Seale

    (Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas)

  • Will A. Vrana

    (Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas)

  • Jai A. Shetake

    (Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas)

  • Sindhu P. Sudanagunta

    (Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas)

  • Michael S. Borland

    (Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas)

  • Michael P. Kilgard

    (Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas)

Abstract

Sound idea for treating tinnitus Neuronal plasticity, the process by which the human brain changes as a result of experience, is thought to be the source of several chronic neurological conditions, including tinnitus. Using a rodent model for noise-induced tinnitus, Engineer et al. find that reversing neural plasticity induced by the tinnitus can correct perceptual impairment. Repeatedly pairing tones with a brief stimulation of the vagus nerve sharpens auditory neuron tuning and eliminates the physiological and behavioural signs of tinnitus. This proof of principle suggests that simply restoring normal neural activity to circuits that have been pathologically modified could provide a benefit in conditions involving aberrant neural plasticity.

Suggested Citation

  • Navzer D. Engineer & Jonathan R. Riley & Jonathan D. Seale & Will A. Vrana & Jai A. Shetake & Sindhu P. Sudanagunta & Michael S. Borland & Michael P. Kilgard, 2011. "Reversing pathological neural activity using targeted plasticity," Nature, Nature, vol. 470(7332), pages 101-104, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7332:d:10.1038_nature09656
    DOI: 10.1038/nature09656
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    Cited by:

    1. Yunseo Ku & Do Youn Kim & Chiheon Kwon & Tae Soo Noh & Moo Kyun Park & Jun Ho Lee & Seung Ha Oh & Hee Chan Kim & Myung-Whan Suh, 2020. "Effect of age on the gap-prepulse inhibition of the cortical N1-P2 complex in humans as a step towards an objective measure of tinnitus," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-17, November.
    2. Michael Boedts & Andreas Buechner & S. Guan Khoo & Welmoed Gjaltema & Frederique Moreels & Anke Lesinski-Schiedat & Philipp Becker & Helen MacMahon & Lieke Vixseboxse & Razieh Taghavi & Hubert H. Lim , 2024. "Combining sound with tongue stimulation for the treatment of tinnitus: a multi-site single-arm controlled pivotal trial," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    3. Konstantin Tziridis & Jana Friedrich & Petra Brüeggemann & Birgit Mazurek & Holger Schulze, 2022. "Estimation of Tinnitus-Related Socioeconomic Costs in Germany," IJERPH, MDPI, vol. 19(16), pages 1-17, August.

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