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Simplifying the screening of gestational diabetes by maternal age plus fasting plasma glucose at first prenatal visit: A prospective cohort study

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  • Yi-Yun Tai
  • Chien-Nan Lee
  • Chun-Heng Kuo
  • Ming-Wei Lin
  • Kuan-Yu Chen
  • Shin-Yu Lin
  • Hung-Yuan Li

Abstract

Aim: The addition of maternal age to fasting plasma glucose (FPG) at 24–28 gestational weeks improves the performance of GDM screening as maternal age increases. However, this method delays the diagnosis of GDM. Since FPG at the first prenatal visit (FPV) is a screening option for pre-existing diabetes, we evaluated the performance of age plus FPG at the FPV to reduce the need for the OGTT. Methods: Pregnant women were recruited consecutively in 2013–2018 (the training cohort) and 2019 (the validation cohort). We excluded women with twin pregnancies, unavailable FPG at the FPV or OGTT data, pre-pregnancy diabetes, or a history of GDM. All participants underwent FPG and haemoglobin A1c (HbA1c) at the FPV and received 75-g OGTT at 24–28 gestational weeks if FPG at the FPV was

Suggested Citation

  • Yi-Yun Tai & Chien-Nan Lee & Chun-Heng Kuo & Ming-Wei Lin & Kuan-Yu Chen & Shin-Yu Lin & Hung-Yuan Li, 2020. "Simplifying the screening of gestational diabetes by maternal age plus fasting plasma glucose at first prenatal visit: A prospective cohort study," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-12, August.
    • Handle: RePEc:plo:pone00:0237224
    DOI: 10.1371/journal.pone.0237224
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    1. Chun-Heng Kuo & Szu-Chi Chen & Chi-Tai Fang & Feng-Jung Nien & En-Tzu Wu & Shin-Yu Lin & Lee-Ming Chuang & Chien-Nan Lee & Hung-Yuan Li, 2017. "Screening gestational diabetes mellitus: The role of maternal age," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-13, March.
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