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Gender difference in ASAS HI among patients with ankylosing spondylitis

Author

Listed:
  • Hsin-Hua Chen
  • Yi-Ming Chen
  • Kuo-Lung Lai
  • Tsu-Yi Hsieh
  • Wei-Ting Hung
  • Ching-Tsai Lin
  • Chih-Wei Tseng
  • Kuo-Tung Tang
  • Yin-Yi Chou
  • Yi-Da Wu
  • Chin-Yin Huang
  • Chia-Wei Hsieh
  • Wen-Nan Huang
  • Yi-Hsing Chen

Abstract

Objective: To assess the associations of the Assessment of Spondyloarthritis International Society Health Index (ASAS HI) with gender and other factors in patients with ankylosing spondylitis (AS). Methods: From November 2017 to October 2018, we measured the Ankylosing Spondylitis Disease Activity Score (ASDAS), the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) and the ASAS HI score for AS patients at the Taichung Veterans General Hospital. After adjusting for disease activity (ASDAS-erythrocyte sedimentation rate [ESR], ASDAS- C-reactive protein [CRP], BASDAI+ESR or BASDAI+CRP), mSASSS and other potential confounders including medications, comorbidities, and laboratory data, any associations between gender and the sum score of ASDAS HI were assessed using multiple linear regression analysis, as well as any associations between gender and an ASAS HI score >5 using multivariable logistic regression analysis. Results: A total of 307 AS patients (62 [20.2%] females, mean age 46.4 years [S.D. 13.3], mean symptom duration 20.6 years [S.D. 12.1]) were included. Multiple linear regression analysis showed that the male gender was significantly associated with a lower ASAS HI (B = -1. 91, 95% confidence interval [CI], −2.82–−1.00, p 5 than females (odds ratio = 0.15, 95% CI, 0.07–0.36, p

Suggested Citation

  • Hsin-Hua Chen & Yi-Ming Chen & Kuo-Lung Lai & Tsu-Yi Hsieh & Wei-Ting Hung & Ching-Tsai Lin & Chih-Wei Tseng & Kuo-Tung Tang & Yin-Yi Chou & Yi-Da Wu & Chin-Yin Huang & Chia-Wei Hsieh & Wen-Nan Huang , 2020. "Gender difference in ASAS HI among patients with ankylosing spondylitis," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-15, July.
    • Handle: RePEc:plo:pone00:0235678
    DOI: 10.1371/journal.pone.0235678
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    1. Ruxandra Schiotis & Nerea Bartolomé & Alejandra Sánchez & Magdalena Szczypiorska & Jesús Sanz & Eduardo Cuende & Eduardo Collantes Estevez & Antonio Martínez & Diego Tejedor & Marta Artieda & Anca Buz, 2012. "Both Baseline Clinical Factors and Genetic Polymorphisms Influence the Development of Severe Functional Status in Ankylosing Spondylitis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
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