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Both Baseline Clinical Factors and Genetic Polymorphisms Influence the Development of Severe Functional Status in Ankylosing Spondylitis

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Listed:
  • Ruxandra Schiotis
  • Nerea Bartolomé
  • Alejandra Sánchez
  • Magdalena Szczypiorska
  • Jesús Sanz
  • Eduardo Cuende
  • Eduardo Collantes Estevez
  • Antonio Martínez
  • Diego Tejedor
  • Marta Artieda
  • Anca Buzoianu
  • Juan Mulero

Abstract

Functional severity in ankylosing spondylitis (AS) patients is variable and difficult to predict early. The aim of our study was to assess whether a combination of baseline clinical factors and genetic markers may predict the development of severe functional status in AS. We performed a cross-sectional association study on AS patients included in the Spanish National Registry of Spondyloarthropathies—REGISPONSER. Bath Ankylosing Spondylitis Functional Index (BASFI) was standardized by adjusting for disease duration since the first symptoms (BASFI/t). We considered as severe functional status the values of BASFI/t in the top of the 60th (p60), 65th (p65), 70th (p70), and 75th (p75) percentile. We selected 384 single nucleotide polymorphisms (SNPs) distributed in 190 genes to be analyzed. The study cohort included 456 patients with mean age 50.8(±10.5) years and with mean disease duration since first symptoms 24.7 (±10.1) years. Older age at disease onset and neck pain at baseline showed statistical significant association with severe BASFI/t. Polymorphisms associated in the allele frequencies test with severe BASFI/t in all classifications were: rs2542151 (p60 [P = .04], p65 [P = .04], p70 [P = .001] and p75 [P = .001]) and rs2254441 (p60 [P = .004], p65 [P = .02], p70 [P = .01] and p75 [P

Suggested Citation

  • Ruxandra Schiotis & Nerea Bartolomé & Alejandra Sánchez & Magdalena Szczypiorska & Jesús Sanz & Eduardo Cuende & Eduardo Collantes Estevez & Antonio Martínez & Diego Tejedor & Marta Artieda & Anca Buz, 2012. "Both Baseline Clinical Factors and Genetic Polymorphisms Influence the Development of Severe Functional Status in Ankylosing Spondylitis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
    • Handle: RePEc:plo:pone00:0043428
    DOI: 10.1371/journal.pone.0043428
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    Cited by:

    1. Hsin-Hua Chen & Yi-Ming Chen & Kuo-Lung Lai & Tsu-Yi Hsieh & Wei-Ting Hung & Ching-Tsai Lin & Chih-Wei Tseng & Kuo-Tung Tang & Yin-Yi Chou & Yi-Da Wu & Chin-Yin Huang & Chia-Wei Hsieh & Wen-Nan Huang , 2020. "Gender difference in ASAS HI among patients with ankylosing spondylitis," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-15, July.

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