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The clinical value of peripheral immune cell counts in pancreatic cancer

Author

Listed:
  • Osama Abu-Shawer
  • Mohammad Abu-Shawer
  • Abdullah Shurman
  • Ali Lattouf
  • Ayman Haimour
  • Omar Hamdan
  • Razan Mansour
  • Tamer Altamimi
  • Maysa Al-Hussaini

Abstract

Background: Elevated neutrophil-lymphocyte ratio (NLR) is linked to poor overall survival (OS) in pancreatic cancer. We aim to investigate the association of the various hematologic markers, in particular NLR among others, with distant metastases, a common feature in pancreatic cancer. Methods: Clinical data from 355 pancreatic cancer patients managed at King Hussein Cancer Center (Amman-Jordan) have been reviewed. We examined the relationship between absolute neutrophil count (ANC), absolute lymphocyte count (ALC), absolute eosinophilic count (AEC), absolute monocytic count (AMC), NLR, monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) with the presence of baseline distant metastases and OS. Receiver Operating Characteristic (ROC) curve analysis was plotted to identify the NLR optimum cutoff value indicative of its association with distant metastases. Results: On univariate and multivariate analyses patients whom on presentation had high NLR (≥3.3) showed more baseline distant metastases compared to patients with low NLR (

Suggested Citation

  • Osama Abu-Shawer & Mohammad Abu-Shawer & Abdullah Shurman & Ali Lattouf & Ayman Haimour & Omar Hamdan & Razan Mansour & Tamer Altamimi & Maysa Al-Hussaini, 2020. "The clinical value of peripheral immune cell counts in pancreatic cancer," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-13, June.
    • Handle: RePEc:plo:pone00:0232043
    DOI: 10.1371/journal.pone.0232043
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    References listed on IDEAS

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    1. Xi Zhang & Wei Zhang & Li-jin Feng, 2014. "Prognostic Significance of Neutrophil Lymphocyte Ratio in Patients with Gastric Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-7, November.
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