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Factors predictive of the success of tuberculosis treatment: A systematic review with meta-analysis

Author

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  • Ninfa Marlen Chaves Torres
  • Jecxy Julieth Quijano Rodríguez
  • Pablo Sebastián Porras Andrade
  • María Belen Arriaga
  • Eduardo Martins Netto

Abstract

Objective: To produce pooled estimates of the global results of tuberculosis (TB) treatment and analyze the predictive factors of successful TB treatment. Methods: Studies published between 2014 and 2019 that reported the results of the treatment of pulmonary TB and the factors that influenced these results. The quality of the studies was evaluated according to the Newcastle-Ottawa quality assessment scale. A random effects model was used to calculate the pooled odds ratio (OR) and 95% confidence interval (CI). This review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) in February 2019 under number CRD42019121512. Results: A total of 151 studies met the criteria for inclusion in this review. The success rate for the treatment of drug-sensitive TB in adults was 80.1% (95% CI: 78.4–81.7). America had the lowest treatment success rate, 75.9% (95% CI: 73.8–77.9), and Oceania had the highest, 83.9% (95% CI: 75.2–91.0). In children, the success rate was 84.8% (95% CI: 77.7–90.7); in patients coinfected with HIV, it was 71.0% (95% CI: 63.7–77.8), in patients with multidrug-resistant TB, it was 58.4% (95% CI: 51.4–64.6), in patients with and extensively drug-resistant TB it was 27.1% (12.7–44.5). Patients with negative sputum smears two months after treatment were almost three times more likely to be successfully treated (OR 2.7; 1.5–4.8), whereas patients younger than 65 years (OR 2.0; 1.7–2.4), nondrinkers (OR 2.0; 1.6–2.4) and HIV-negative patients (OR 1.9; 1.6–2.5 3) were two times more likely to be successfully treated. Conclusion: The success of TB treatment at the global level was good, but was still below the defined threshold of 85%. Factors such as age, sex, alcohol consumption, smoking, lack of sputum conversion at two months of treatment and HIV affected the success of TB treatment.

Suggested Citation

  • Ninfa Marlen Chaves Torres & Jecxy Julieth Quijano Rodríguez & Pablo Sebastián Porras Andrade & María Belen Arriaga & Eduardo Martins Netto, 2019. "Factors predictive of the success of tuberculosis treatment: A systematic review with meta-analysis," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-24, December.
    • Handle: RePEc:plo:pone00:0226507
    DOI: 10.1371/journal.pone.0226507
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    References listed on IDEAS

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    1. Narges Alipanah & Leah Jarlsberg & Cecily Miller & Nguyen Nhat Linh & Dennis Falzon & Ernesto Jaramillo & Payam Nahid, 2018. "Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies," PLOS Medicine, Public Library of Science, vol. 15(7), pages 1-44, July.
    2. Leonela Villegas & Larissa Otero & Timothy R Sterling & Moises A Huaman & Patrick Van der Stuyft & Eduardo Gotuzzo & Carlos Seas, 2016. "Prevalence, Risk Factors, and Treatment Outcomes of Isoniazid- and Rifampicin- Mono-Resistant Pulmonary Tuberculosis in Lima, Peru," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-11, April.
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    1. Farman Ullah Khan & Asim ur Rehman & Faiz Ullah Khan & Khezar Hayat & Amjad Khan & Nafees Ahmad & Jie Chang & Usman Rashid Malik & Yu Fang, 2022. "Assessment of Factors Associated with Unfavorable Outcomes among Drug-Resistant TB Patients: A 6-Year Retrospective Study from Pakistan," IJERPH, MDPI, vol. 19(3), pages 1-13, January.

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