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Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix)

Author

Listed:
  • Ryan S Senger
  • Varun Kavuru
  • Meaghan Sullivan
  • Austin Gouldin
  • Stephanie Lundgren
  • Kristen Merrifield
  • Caitlin Steen
  • Emily Baker
  • Tommy Vu
  • Ben Agnor
  • Gabrielle Martinez
  • Hana Coogan
  • William Carswell
  • Lampros Karageorge
  • Devasmita Dev
  • Pang Du
  • Allan Sklar
  • Giuseppe Orlando
  • James Pirkle Jr
  • John L Robertson

Abstract

Raman chemometric urinalysis (Rametrix™) was used to analyze 235 urine specimens from healthy individuals. The purpose of this study was to establish the “range of normal” for Raman spectra of urine specimens from healthy individuals. Ultimately, spectra falling outside of this range will be correlated with kidney and urinary tract disease. Rametrix™ analysis includes direct comparisons of Raman spectra but also principal component analysis (PCA), discriminant analysis of principal components (DAPC) models, multivariate statistics, and it is available through GitHub as the Rametrix™ LITE Toolbox for MATLAB®. Results showed consistently overlapping Raman spectra of urine specimens with significantly larger variances in Raman shifts, found by PCA, corresponding to urea, creatinine, and glucose concentrations. A 2-way ANOVA test found that age of the urine specimen donor was statistically significant (p

Suggested Citation

  • Ryan S Senger & Varun Kavuru & Meaghan Sullivan & Austin Gouldin & Stephanie Lundgren & Kristen Merrifield & Caitlin Steen & Emily Baker & Tommy Vu & Ben Agnor & Gabrielle Martinez & Hana Coogan & Wil, 2019. "Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix)," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-11, September.
    • Handle: RePEc:plo:pone00:0222115
    DOI: 10.1371/journal.pone.0222115
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    References listed on IDEAS

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    1. Adam Shardlow & Natasha J McIntyre & Simon D S Fraser & Paul Roderick & James Raftery & Richard J Fluck & Christopher W McIntyre & Maarten W Taal, 2017. "The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study," PLOS Medicine, Public Library of Science, vol. 14(10), pages 1-18, October.
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    1. Ryan S Senger & Meaghan Sullivan & Austin Gouldin & Stephanie Lundgren & Kristen Merrifield & Caitlin Steen & Emily Baker & Tommy Vu & Ben Agnor & Gabrielle Martinez & Hana Coogan & William Carswell &, 2020. "Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix)," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-12, January.

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