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Interactive effects of OXTR and GAD1 on envy-associated behaviors and neural responses

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  • Toshiko Tanaka
  • Fumichika Nishimura
  • Chihiro Kakiuchi
  • Kiyoto Kasai
  • Minoru Kimura
  • Masahiko Haruno

Abstract

Inequity aversion (negative feelings induced by outcome differences between the self and other) plays a key role in human social behaviors. The neurotransmitters oxytocin and GABA have been implicated in neural responses to inequity. However, it remains poorly understood not only how individual genetic factors related to oxytocin and GABA affect the neural mechanisms behind inequity aversion, but also how these genes interact. To address these issues, we examined relationships between genotypes, behavioral decisions and brain activities during the ultimatum game. We identified interactive effects between the polymorphisms of the oxytocin receptor gene (OXTR) and glutamate decarboxylase 1 gene for GABA synthesis (GAD1) on envy aversion (i.e., disadvantageous inequity aversion) and on envy-induced activity in the dorsal ACC (dACC). Thus, our integrated approach suggested interactive genetic effects between OXTR and GAD1 on envy aversion and the underlying neural substrates.

Suggested Citation

  • Toshiko Tanaka & Fumichika Nishimura & Chihiro Kakiuchi & Kiyoto Kasai & Minoru Kimura & Masahiko Haruno, 2019. "Interactive effects of OXTR and GAD1 on envy-associated behaviors and neural responses," PLOS ONE, Public Library of Science, vol. 14(1), pages 1-17, January.
    • Handle: RePEc:plo:pone00:0210493
    DOI: 10.1371/journal.pone.0210493
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    1. Katarina Gospic & Erik Mohlin & Peter Fransson & Predrag Petrovic & Magnus Johannesson & Martin Ingvar, 2011. "Limbic Justice—Amygdala Involvement in Immediate Rejection in the Ultimatum Game," PLOS Biology, Public Library of Science, vol. 9(5), pages 1-8, May.
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