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Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy

Author

Listed:
  • Yukihiro Wada
  • Kei Matsumoto
  • Taihei Suzuki
  • Tomohiro Saito
  • Nobuhiro Kanazawa
  • Shohei Tachibana
  • Ken Iseri
  • Motonori Sugiyama
  • Masayuki Iyoda
  • Takanori Shibata

Abstract

Introduction: Galactose-deficient IgA1 (Gd-IgA1) is a critical pathogenic factor for IgA nephropathy (IgAN), but its value as a disease-specific biomarker remains controversial. We aimed to clarify the clinical significance of Gd-IgA1 in patients with IgAN. Methods: We retrospectively reviewed 111 patients who were diagnosed with IgAN based on the findings of renal biopsies (RB) at Showa University Hospital since 2007. Serum Gd-IgA1 (s-Gd-IgA1) at the time of RB was compared among 111 IgAN patients, 18 Henoch-Schönlein purpura nephritis (HSPN) patients, 29 lupus nephritis (LN) patients, 28 ANCA-associated vasculitis (AAV) patients, and 13 minimal change disease (MCD) patients using ELISA with an anti-human Gd-IgA1-specific monoclonal antibody (KM55). We also immunohistochemically stained paraffin-embedded sections for mesangial Gd-IgA1 (m-Gd-IgA1) deposition using KM55. Results: Although levels of s-Gd-IgA1 were comparable among IgAN and HSPN, s-Gd-IgA1 levels were significantly elevated in patients with IgAN compared with LN, AAV and MCD (IgAN vs. HSPN, LN, AAV, and MCD: 16.2 ± 9.1 vs. 14.2 ± 10.8, p = 0.263; 12.7 ± 9.4, p = 0.008; 13.1 ± 7.3, p = 0.059; and 8.2 ± 4.8 μg/mL, p

Suggested Citation

  • Yukihiro Wada & Kei Matsumoto & Taihei Suzuki & Tomohiro Saito & Nobuhiro Kanazawa & Shohei Tachibana & Ken Iseri & Motonori Sugiyama & Masayuki Iyoda & Takanori Shibata, 2018. "Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-17, November.
    • Handle: RePEc:plo:pone00:0206865
    DOI: 10.1371/journal.pone.0206865
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    References listed on IDEAS

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    1. Qiang Sun & Zhenhai Zhang & Hong Zhang & Xiaorong Liu, 2016. "Aberrant IgA1 Glycosylation in IgA Nephropathy: A Systematic Review," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-15, November.
    2. Min Jeong Kim & Stefan Schaub & Karen Molyneux & Michael T Koller & Susanne Stampf & Jonathan Barratt, 2016. "Effect of Immunosuppressive Drugs on the Changes of Serum Galactose-Deficient IgA1 in Patients with IgA Nephropathy," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-11, December.
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