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Effect of Immunosuppressive Drugs on the Changes of Serum Galactose-Deficient IgA1 in Patients with IgA Nephropathy

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  • Min Jeong Kim
  • Stefan Schaub
  • Karen Molyneux
  • Michael T Koller
  • Susanne Stampf
  • Jonathan Barratt

Abstract

Galactose-deficient IgA1 (Gd-IgA1) and IgA-IgG complexes are known to play an important role in the pathogenesis of IgA nephropathy (IgAN). We aimed therefore to determine the impact of immunosuppression on the serum levels of Gd-IgA1, total IgA1 and IgA-IgG complexes in IgAN patients. In a retrospective study, serum samples from IgAN patients collected before transplantation (t0) and at 3- and 6-month posttransplant (t3 & t6) were used to measure the levels of Gd-IgA1, total IgA1 and IgA-IgG complexes. The area under the curves (AUC) of immunosuppressants was calculated by the plot of plasma trough level or dosage of each immunosuppressant versus time and was interpreted as the extent of drug exposure. Thirty-six out of 64 IgAN patients, who underwent kidney transplantation between 2005 and 2012, were enrolled. From t0 to t3, serum Gd-IgA1 and total IgA1 decreased significantly (24.7 AU (18.6–36.1) to 17.2 (13.1–29.5) (p

Suggested Citation

  • Min Jeong Kim & Stefan Schaub & Karen Molyneux & Michael T Koller & Susanne Stampf & Jonathan Barratt, 2016. "Effect of Immunosuppressive Drugs on the Changes of Serum Galactose-Deficient IgA1 in Patients with IgA Nephropathy," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-11, December.
    • Handle: RePEc:plo:pone00:0166830
    DOI: 10.1371/journal.pone.0166830
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    Cited by:

    1. Motonori Sugiyama & Yukihiro Wada & Nobuhiro Kanazawa & Shohei Tachibana & Taihei Suzuki & Kei Matsumoto & Masayuki Iyoda & Hirokazu Honda & Takanori Shibata, 2020. "A cross-sectional analysis of clinicopathologic similarities and differences between Henoch-Schönlein purpura nephritis and IgA nephropathy," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-20, April.
    2. Yukihiro Wada & Kei Matsumoto & Taihei Suzuki & Tomohiro Saito & Nobuhiro Kanazawa & Shohei Tachibana & Ken Iseri & Motonori Sugiyama & Masayuki Iyoda & Takanori Shibata, 2018. "Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-17, November.

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