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The effect of neonatal hypothyroidism and low family income on intellectual disability: A population-based cohort study

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  • Jin Young Nam
  • Young Choi
  • Mo Kyung Jung
  • Jaeyong Shin
  • Kyoung Hee Cho
  • Woorim Kim
  • Eun-Cheol Park

Abstract

Background: To investigate relationships among neonatal hypothyroidism, family income, and intellectual disability, as well as the combined effects of neonatal hypothyroidism and low family income on intellectual disability. Methods: Data were extracted from the National Health Insurance Service-National Sample Cohort from 2002 to 2011. This retrospective study included 91,247 infants. The presence of intellectual disability was based on the disability evaluation system in Korea. Newborn hypothyroidism was identified from diagnosis and prescription codes. Family income was determined from average monthly insurance premiums. Cox proportional hazards models were used to calculate adjusted hazard ratios. Results: Of the 91,247 infants, 208 were considered to have intellectual disability (29.18 cases per 100,000 person-year). The risk of intellectual disability was higher in infants with hypothyroidism than in those without hypothyroidism (hazard ratio = 5.28, P:

Suggested Citation

  • Jin Young Nam & Young Choi & Mo Kyung Jung & Jaeyong Shin & Kyoung Hee Cho & Woorim Kim & Eun-Cheol Park, 2018. "The effect of neonatal hypothyroidism and low family income on intellectual disability: A population-based cohort study," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0205955
    DOI: 10.1371/journal.pone.0205955
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    References listed on IDEAS

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    1. Leonard, Helen & Petterson, Beverly & De Klerk, Nicholas & Zubrick, Stephen R. & Glasson, Emma & Sanders, Richard & Bower, Carol, 2005. "Association of sociodemographic characteristics of children with intellectual disability in Western Australia," Social Science & Medicine, Elsevier, vol. 60(7), pages 1499-1513, April.
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