IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0200271.html
   My bibliography  Save this article

Associations between perfluorinated chemicals and serum biochemical markers and performance status in uremic patients under hemodialysis

Author

Listed:
  • Wen-Sheng Liu
  • Yen-Ting Lai
  • Hsiang-Lin Chan
  • Szu-Yuan Li
  • Chih-Ching Lin
  • Chih-Kuang Liu
  • Han-Hsing Tsou
  • Tsung-Yun Liu

Abstract

Perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA) are commonly used perfluorinated chemicals (PFCs). PFCs are mainly excreted by urine. Uremic patients tend to accumulate toxins in their body and have poor functional status. We investigated the associations between PFCs and the clinical profile of uremic patients under hemodialysis (HD). Liquid chromatography tandem mass spectrometry coupled with isotope dilution was used to quantify PFOA and PFOS. We enrolled 126 patients under regular HD. Compared with previous research, the concentration of PFOA was lower, but that of PFOS was higher in uremic patients than in the general population. The levels of PFOA and PFOS in uremic patients before dialysis were 0.52 (ng/ml) and 21.84 (ng/ml) respectively. The PFOA level remained unchanged but that of PFOS decreased to1.85 ng/mL after dialysis. PFOS can be removed by HD. Patients using hypertensive medication had a lower PFOS then those who did not. The PFOS level was negatively correlated with the duration of the HD session and patient performance status, but positively correlated with levels of cholesterol, chloride (an indicator of acidemia), ferritin, and total protein. (p

Suggested Citation

  • Wen-Sheng Liu & Yen-Ting Lai & Hsiang-Lin Chan & Szu-Yuan Li & Chih-Ching Lin & Chih-Kuang Liu & Han-Hsing Tsou & Tsung-Yun Liu, 2018. "Associations between perfluorinated chemicals and serum biochemical markers and performance status in uremic patients under hemodialysis," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-13, July.
    • Handle: RePEc:plo:pone00:0200271
    DOI: 10.1371/journal.pone.0200271
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200271
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0200271&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0200271?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wen-Sheng Liu & Hsiang Lin Chan & Yen-Ting Lai & Chih-Ching Lin & Szu-Yuan Li & Chih-Kuang Liu & Han-Hsing Tsou & Tsung-Yun Liu, 2018. "Dialysis Membranes Influence Perfluorochemical Concentrations and Liver Function in Patients on Hemodialysis," IJERPH, MDPI, vol. 15(11), pages 1-12, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0200271. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.