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Effects of tumor necrosis factor inhibitors and tocilizumab on the glycosylated hemoglobin levels in patients with rheumatoid arthritis; an observational study

Author

Listed:
  • Yukimi Otsuka
  • Chikako Kiyohara
  • Yusuke Kashiwado
  • Takuya Sawabe
  • Shuji Nagano
  • Yasutaka Kimoto
  • Masahiro Ayano
  • Hiroki Mitoma
  • Mitsuteru Akahoshi
  • Yojiro Arinobu
  • Hiroaki Niiro
  • Koichi Akashi
  • Takahiko Horiuchi

Abstract

Rheumatoid arthritis (RA) and diabetes mellitus (DM) are associated with inflammation. We tried to investigate the influence of tumor necrosis factor inhibitors (TNFi) and tocilizumab (TCZ) on the glucose metabolism of RA patients. RA patients in whom treatment with TNFi or TCZ was initiated from 2008 to 2015 were studied based on their medical records. We analyzed patients whose glycosylated hemoglobin (HbA1c) levels were measured both before and 3 months after the initiation of these biologic agents. The association between HbA1c reduction and the treatment was evaluated. From 971 cases treated with these biologic agents, 221 cases whose medical records of HbA1c were available, were included (TNFi, n = 154; TCZ, n = 67). Both the TNFi and TCZ groups had significantly lower HbA1c values at 1 month and 3 months after the initiation of treatment (TNFi, p

Suggested Citation

  • Yukimi Otsuka & Chikako Kiyohara & Yusuke Kashiwado & Takuya Sawabe & Shuji Nagano & Yasutaka Kimoto & Masahiro Ayano & Hiroki Mitoma & Mitsuteru Akahoshi & Yojiro Arinobu & Hiroaki Niiro & Koichi Aka, 2018. "Effects of tumor necrosis factor inhibitors and tocilizumab on the glycosylated hemoglobin levels in patients with rheumatoid arthritis; an observational study," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-16, April.
    • Handle: RePEc:plo:pone00:0196368
    DOI: 10.1371/journal.pone.0196368
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    References listed on IDEAS

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    1. Leena R Baghdadi & Richard J Woodman & E Michael Shanahan & Arduino A Mangoni, 2015. "The Impact of Traditional Cardiovascular Risk Factors on Cardiovascular Outcomes in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-18, February.
    2. Motomu Hashimoto & Takao Fujii & Masahide Hamaguchi & Moritoshi Furu & Hiromu Ito & Chikashi Terao & Keiichi Yamamoto & Wataru Yamamoto & Takashi Matsuo & Masato Mori & Koichiro Ohmura & Hiroshi Kawab, 2014. "Increase of Hemoglobin Levels by Anti-IL-6 Receptor Antibody (Tocilizumab) in Rheumatoid Arthritis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-7, May.
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