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Increase of Hemoglobin Levels by Anti-IL-6 Receptor Antibody (Tocilizumab) in Rheumatoid Arthritis

Author

Listed:
  • Motomu Hashimoto
  • Takao Fujii
  • Masahide Hamaguchi
  • Moritoshi Furu
  • Hiromu Ito
  • Chikashi Terao
  • Keiichi Yamamoto
  • Wataru Yamamoto
  • Takashi Matsuo
  • Masato Mori
  • Koichiro Ohmura
  • Hiroshi Kawabata
  • Tsuneyo Mimori

Abstract

Objective: To compare the effect of tocilizumab (TCZ) with other biologic therapies in improving anemia of rheumatoid arthritis (RA) patients. Methods: We compared the change of hemoglobin (Hb) levels in a cohort of 147 consecutive RA patients who were treated with biologics for more than 12 weeks. Twenty eight patients were treated with TCZ, and 119 patients were treated with biologics other than TCZ (87 with TNF inhibitors and 32 with abatacept). The change of Hb levels from baseline to week 12 was compared between the TCZ and the non-TCZ groups. We performed univariate and multivariate analyses with adjustment of potential confounders such as baseline characteristics, concomitant treatment, and the clinical response to treatment. Results: Hb levels generally increased after biologic therapies both in the TCZ and the non-TCZ groups. The increase of Hb levels was greater in the TCZ group than in the non-TCZ groups (1.1 g/dL in the TCZ group vs 0.3 g/dL in the non-TCZ group, p = 0.009). Univariate analysis revealed that increase of Hb levels was also significantly associated with lower Hb, higher Low Hemoglobin Density, and higher CRP levels at baseline and greater reduction in the clinical disease activity index. TCZ therapy was significantly associated with the increase of Hb levels even after adjustment for these factors by multivariate analysis (p

Suggested Citation

  • Motomu Hashimoto & Takao Fujii & Masahide Hamaguchi & Moritoshi Furu & Hiromu Ito & Chikashi Terao & Keiichi Yamamoto & Wataru Yamamoto & Takashi Matsuo & Masato Mori & Koichiro Ohmura & Hiroshi Kawab, 2014. "Increase of Hemoglobin Levels by Anti-IL-6 Receptor Antibody (Tocilizumab) in Rheumatoid Arthritis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-7, May.
    • Handle: RePEc:plo:pone00:0098202
    DOI: 10.1371/journal.pone.0098202
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    1. Chikashi Terao & Motomu Hashimoto & Keiichi Yamamoto & Kosaku Murakami & Koichiro Ohmura & Ran Nakashima & Noriyuki Yamakawa & Hajime Yoshifuji & Naoichiro Yukawa & Daisuke Kawabata & Takashi Usui & H, 2013. "Three Groups in the 28 Joints for Rheumatoid Arthritis Synovitis – Analysis Using More than 17,000 Assessments in the KURAMA Database," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-6, March.
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    1. Yukimi Otsuka & Chikako Kiyohara & Yusuke Kashiwado & Takuya Sawabe & Shuji Nagano & Yasutaka Kimoto & Masahiro Ayano & Hiroki Mitoma & Mitsuteru Akahoshi & Yojiro Arinobu & Hiroaki Niiro & Koichi Aka, 2018. "Effects of tumor necrosis factor inhibitors and tocilizumab on the glycosylated hemoglobin levels in patients with rheumatoid arthritis; an observational study," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-16, April.

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