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Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies

Author

Listed:
  • Fei Cheng
  • Mi Zhang
  • Quan Wang
  • Haijun Xu
  • Xiao Dong
  • Zhen Gao
  • Jiajuan Chen
  • Yunjie Wei
  • Fen Qin

Abstract

Conflicting results identifying the association between tooth loss and cardiovascular disease and stroke have been reported. Therefore, a dose-response meta-analysis was performed to clarify and quantitatively assess the correlation between tooth loss and cardiovascular disease and stroke risk. Up to March 2017, seventeen cohort studies were included in current meta-analysis, involving a total of 879084 participants with 43750 incident cases. Our results showed statistically significant increment association between tooth loss and cardiovascular disease and stroke risk. Subgroups analysis indicated that tooth loss was associated with a significant risk of cardiovascular disease and stroke in Asia and Caucasian. Furthermore, tooth loss was associated with a significant risk of cardiovascular disease and stroke in fatal cases and nonfatal cases. Additionally, a significant dose-response relationship was observed between tooth loss and cardiovascular disease and stroke risk. Increasing per 2 of tooth loss was associated with a 3% increment of coronary heart disease risk; increasing per 2 of tooth loss was associated with a 3% increment of stroke risk. Subgroup meta-analyses in study design, study quality, number of participants and number of cases showed consistent findings. No publication bias was observed in this meta-analysis. Considering these promising results, tooth loss might provide harmful health benefits.

Suggested Citation

  • Fei Cheng & Mi Zhang & Quan Wang & Haijun Xu & Xiao Dong & Zhen Gao & Jiajuan Chen & Yunjie Wei & Fen Qin, 2018. "Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-14, March.
    • Handle: RePEc:plo:pone00:0194563
    DOI: 10.1371/journal.pone.0194563
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    References listed on IDEAS

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    1. Richard G Watt & Georgios Tsakos & Cesar de Oliveira & Mark Hamer, 2012. "Tooth Loss and Cardiovascular Disease Mortality Risk – Results from the Scottish Health Survey," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-7, February.
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