IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0127642.html
   My bibliography  Save this article

Examination of the Relationship between Oral Health and Arterial Sclerosis without Genetic Confounding through the Study of Older Japanese Twins

Author

Listed:
  • Yuko Kurushima
  • Kazunori Ikebe
  • Ken-ichi Matsuda
  • Kaori Enoki
  • Soshiro Ogata
  • Motozo Yamashita
  • Shinya Murakami
  • Yoshinobu Maeda
  • Osaka Twin Research Group

Abstract

Objective: Although researchers have recently demonstrated a relationship between oral health and arterial sclerosis, the genetic contribution to this relationship has been ignored even though genetic factors are expected to have some effect on various diseases. The aim of this study was to evaluate oral health as a significant risk factor related to arterial sclerosis after eliminating genetic confounding through study of older Japanese twins. Subjects and Methods: Medical and dental surveys were conducted individually for 106 Japanese twin pairs over the age of 50 years. Maximal carotid intima-media thickness (IMT-Cmax) was measured as a surrogate marker of arterial sclerosis. IMT-Cmax > 1.0 mm was diagnosed as arterial sclerosis. All of the twins were examined for the number of remaining teeth, masticatory performance, and periodontal status. We evaluated each measurement related with IMT-Cmax and arterial sclerosis using generalized estimating equations analysis adjusted for potential risk factors. For non-smoking monozygotic twins, a regression analysis using a “between within” model was conducted to evaluate the relationship between IMT-Cmax and the number of teeth as the environmental factor controlling genetic and familial confounding. Results: We examined 91 monozygotic and 15 dizygotic twin pairs (males: 42, females: 64) with a mean (± standard deviation) age of 67.4 ± 10.0 years. Out of all of the oral health-related measurements collected, only the number of teeth was significantly related to arterial sclerosis (odds ratio: 0.72, 95% confidence interval: 0.52-0.99 per five teeth). Regression analysis showed a significant association between the IMT-Cmax and the number of teeth as an environmental factor (p = 0.037). Conclusions: Analysis of monozygotic twins older than 50 years of age showed that having fewer teeth could be a significant environmental factor related to arterial sclerosis, even after controlling for genetic and familial confounding.

Suggested Citation

  • Yuko Kurushima & Kazunori Ikebe & Ken-ichi Matsuda & Kaori Enoki & Soshiro Ogata & Motozo Yamashita & Shinya Murakami & Yoshinobu Maeda & Osaka Twin Research Group, 2015. "Examination of the Relationship between Oral Health and Arterial Sclerosis without Genetic Confounding through the Study of Older Japanese Twins," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0127642
    DOI: 10.1371/journal.pone.0127642
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127642
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0127642&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0127642?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Richard G Watt & Georgios Tsakos & Cesar de Oliveira & Mark Hamer, 2012. "Tooth Loss and Cardiovascular Disease Mortality Risk – Results from the Scottish Health Survey," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-7, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Fei Cheng & Mi Zhang & Quan Wang & Haijun Xu & Xiao Dong & Zhen Gao & Jiajuan Chen & Yunjie Wei & Fen Qin, 2018. "Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-14, March.
    2. Shang-Jung Wu & Chun-Chieh Wang & Shu-Chen Kuo & Shwn-Huey Shieh & Yueh-Juen Hwu, 2020. "Evaluation of an Oral Hygiene Education Program for Staff Providing Long-Term Care Services: A Mixed Methods Study," IJERPH, MDPI, vol. 17(12), pages 1-13, June.
    3. Xiaomin Qu & Xiang Qi & Bei Wu, 2020. "Disparities in Dental Service Utilization among Adults in Chinese Megacities: Do Health Insurance and City of Residence Matter?," IJERPH, MDPI, vol. 17(18), pages 1-13, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0127642. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.