IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0193834.html
   My bibliography  Save this article

Time to acquire and lose carriership of ESBL/pAmpC producing E. coli in humans in the Netherlands

Author

Listed:
  • Peter F M Teunis
  • Eric G Evers
  • Paul D Hengeveld
  • Cindy M Dierikx
  • Cornelia C C H Wielders
  • Engeline van Duijkeren

Abstract

A subset of the study population from a cross–sectional study of carriership of ESBL/pAmpC–producing E. coli (ESBL–E) in the general population was followed up by five successive samples over an approximate half year period, leading to six samples in 333 persons. Fecal samples were cultured and analyzed for the presence of E. coli types as characterized by MLST, and ESBL/pAmpC genes were analysed by PCR and sequencing. The study included 255 persons who had a negative first sample, to allow observations of acquiring carriership of ESBL–E. Any individual record thus consisted of a series of snapshots of episodes of presence and absence of ESBL–E carriage. A survival model was built to estimate times to acquire or lose carriership, allowing for any combination of ESBL/pAmpC gene and E. coli MLST type. In carriers, the mean time to lose carriership was 1.1 (95% range 0.8–1.6) years. The estimated mean time to acquire carriership was 3.0 (95% range 1.6–6.3) years. Analysis of these times by ESBL/pAmpC gene found substantial variation among resistance genes both in persistence of carriership and in rates of acquiring carriership: blaCTX-M-1, blaCTX-M-14, blaCTX-M-15, blaCTX-M-27 and blaSHV-12 were easily acquired, but blaCTX-M-1 and blaSHV-12 were also easily lost, while blaCTX-M-15, blaCTX-M-27 and blaCMY-2 were more likely to persist. When in addition bacterial host types were included, some combinations appeared more persistent than others (blaCTX-M-1 in ST10 and ST58; blaCTX-M-14, blaCMY-2, and blaSHV-12 in ST69), or were acquired with higher frequency (blaCTX-M-14 in ST38, ST69, and ST131; blaCTX-M-15 and blaCTX-M-27 in ST131; blaSHV-12 in ST69). The relatively short duration of carriership means that when an intervention drastically reduces the exposure of humans to ESBL-E, the prevalence will be halved in 0.66 years. The observed differences between carriage rates of ESBL/pAmpC genes and E. coli strains need further investigation.

Suggested Citation

  • Peter F M Teunis & Eric G Evers & Paul D Hengeveld & Cindy M Dierikx & Cornelia C C H Wielders & Engeline van Duijkeren, 2018. "Time to acquire and lose carriership of ESBL/pAmpC producing E. coli in humans in the Netherlands," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-14, March.
  • Handle: RePEc:plo:pone00:0193834
    DOI: 10.1371/journal.pone.0193834
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193834
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0193834&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0193834?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Glen A. Satten & Maya R. Sternberg, 1999. "Fitting Semi-Markov Models to Interval-Censored Data with Unknown Initiation Times," Biometrics, The International Biometric Society, vol. 55(2), pages 507-513, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Marc Chadeau‐Hyam & Paul S. Clarke & Chantal Guihenneuc‐Jouyaux & Simon N. Cousens & Robert G. Will & Azra C. Ghani, 2010. "An application of hidden Markov models to the French variant Creutzfeldt–Jakob disease epidemic," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 59(5), pages 839-853, November.
    2. Andrea Arfè & Stefano Peluso & Pietro Muliere, 2021. "The semi-Markov beta-Stacy process: a Bayesian non-parametric prior for semi-Markov processes," Statistical Inference for Stochastic Processes, Springer, vol. 24(1), pages 1-15, April.
    3. E. Mathieu & Y. Foucher & P. Dellamonica & J. P. Daures, 2007. "Parametric and Non Homogeneous Semi-Markov Process for HIV Control," Methodology and Computing in Applied Probability, Springer, vol. 9(3), pages 389-397, September.
    4. Andrew C. Titman & Linda D. Sharples, 2010. "Semi-Markov Models with Phase-Type Sojourn Distributions," Biometrics, The International Biometric Society, vol. 66(3), pages 742-752, September.
    5. Glen A. Satten, 1999. "Estimating the Extent of Tracking in Interval-Censored Chain-Of-Events Data," Biometrics, The International Biometric Society, vol. 55(4), pages 1228-1231, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0193834. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.