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Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: A pilot case-control study

Author

Listed:
  • Chihiro Kaneko
  • Tetsuo Kobayashi
  • Satoshi Ito
  • Noriko Sugita
  • Akira Murasawa
  • Kiyoshi Nakazono
  • Hiromasa Yoshie

Abstract

Objectives: An interrelationship between rheumatoid arthritis (RA) and periodontitis has been suggested due to their common pathogenic mechanisms. Protein carbamylation and neutrophil extracellular traps (NETs) formation have been shown to be related to autoimmune conditions, including RA, but their association with periodontitis has not been elucidated. Therefore, we assessed whether or not circulating levels of carbamylated protein (CarP) and NETs are associated with periodontitis severity and influenced by periodontal treatment. Methods: We conducted a retrospective case-control study that included 40 patients with RA and periodontitis, 30 patients with periodontitis, and 43 systemically and periodontally healthy controls to assess the circulating levels of CarP and NETs and rheumatologic and periodontal conditions. The same assessments were also performed in 22 patients with RA and periodontitis after 2 months of periodontal treatment, including oral hygiene instruction and full-mouth supragingival scaling. Results: Patients with RA and periodontitis showed significantly higher serum levels of CarP and NETs than the control group (P = 0.04 and P

Suggested Citation

  • Chihiro Kaneko & Tetsuo Kobayashi & Satoshi Ito & Noriko Sugita & Akira Murasawa & Kiyoshi Nakazono & Hiromasa Yoshie, 2018. "Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: A pilot case-control study," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-15, February.
    • Handle: RePEc:plo:pone00:0192365
    DOI: 10.1371/journal.pone.0192365
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