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Efficacy and safety of Modified Tongxie Yaofang in diarrhea-predominant irritable bowel syndrome management: A meta-analysis of randomized, positive medicine-controlled trials

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  • Yun-kai Dai
  • Dan-yan Li
  • Yun-zhan Zhang
  • Meng-xin Huang
  • Yi-le Zhou
  • Jin-tong Ye
  • Qi Wang
  • Ling Hu

Abstract

Objective: To systematically evaluate the efficacy and safety of Modified Tongxie Yaofang (M-TXYF) for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D). Method: Electronic databases including PubMed, Springer Link, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature (CBM), Wanfang, and Chinese Scientific Journals Database (VIP) were conducted from their inception through May 11, 2017 without language restrictions. Primary and secondary outcomes were estimated by 95% confidence intervals (CI). RevMan 5.3 and the Cochrane Collaboration’s risk of bias tool were analyzed for this meta-analysis. Results: Twenty-three literatures with a total of 1972 patients were included for the meta-analysis. The overall risk of bias evaluation was low. The pooled odds ratio showed that M-TXYF was significantly superior to routine pharmacotherapies (RP) in clinical therapeutic efficacy (OR 4.04, 95% CI 3.09, 5.27, P

Suggested Citation

  • Yun-kai Dai & Dan-yan Li & Yun-zhan Zhang & Meng-xin Huang & Yi-le Zhou & Jin-tong Ye & Qi Wang & Ling Hu, 2018. "Efficacy and safety of Modified Tongxie Yaofang in diarrhea-predominant irritable bowel syndrome management: A meta-analysis of randomized, positive medicine-controlled trials," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-18, February.
    • Handle: RePEc:plo:pone00:0192319
    DOI: 10.1371/journal.pone.0192319
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    References listed on IDEAS

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    1. Ya Xiao & Yanyan Liu & Shaohui Huang & Xiaomin Sun & Yang Tang & Jingru Cheng & Tian Wang & Fei Li & Yuxiang Kuang & Ren Luo & Xiaoshan Zhao, 2015. "The Efficacy of Shugan Jianpi Zhixie Therapy for Diarrhea-Predominant Irritable Bowel Syndrome: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-12, April.
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