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The Efficacy of Shugan Jianpi Zhixie Therapy for Diarrhea-Predominant Irritable Bowel Syndrome: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials

Author

Listed:
  • Ya Xiao
  • Yanyan Liu
  • Shaohui Huang
  • Xiaomin Sun
  • Yang Tang
  • Jingru Cheng
  • Tian Wang
  • Fei Li
  • Yuxiang Kuang
  • Ren Luo
  • Xiaoshan Zhao

Abstract

Background: Shugan Jianpi Zhixie therapy (SJZT) has been widely used to treat diarrhea-predominant irritable bowel syndrome (IBS-D), but the results are still controversial. A meta-analysis of randomized, double-blind, placebo-controlled trials was performed to assess the efficacy and tolerability of SJZT for IBS-D. Methods: The MEDLINE, EMBASE, Cochrane Library, the China National Knowledge Infrastructure database, the Chinese Biomedical Literature database and the Wanfang database were searched up to June 2014 with no language restrictions. Summary estimates, including 95% confidence intervals (CI), were calculated for global symptom improvement, abdominal pain improvement, and Symptom Severity Scale (BSS) score. Results: Seven trials (N=954) were included. The overall risk of bias assessment was low. SJZT showed significant improvement for global symptom compared to placebo (RR 1.61; 95% CI 1.24, 2.10; P =0.0004; therapeutic gain = 33.0%; number needed to treat (NNT) = 3.0). SJZT was significantly more likely to reduce overall BSS score (SMD –0.67; 95% CI –0.94, –0.40; P

Suggested Citation

  • Ya Xiao & Yanyan Liu & Shaohui Huang & Xiaomin Sun & Yang Tang & Jingru Cheng & Tian Wang & Fei Li & Yuxiang Kuang & Ren Luo & Xiaoshan Zhao, 2015. "The Efficacy of Shugan Jianpi Zhixie Therapy for Diarrhea-Predominant Irritable Bowel Syndrome: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-12, April.
    • Handle: RePEc:plo:pone00:0122397
    DOI: 10.1371/journal.pone.0122397
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    Cited by:

    1. Yun-kai Dai & Dan-yan Li & Yun-zhan Zhang & Meng-xin Huang & Yi-le Zhou & Jin-tong Ye & Qi Wang & Ling Hu, 2018. "Efficacy and safety of Modified Tongxie Yaofang in diarrhea-predominant irritable bowel syndrome management: A meta-analysis of randomized, positive medicine-controlled trials," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-18, February.
    2. Dan-yan Li & Yun-kai Dai & Yun-zhan Zhang & Meng-xin Huang & Ru-liu Li & Jia Ou-yang & Wei-jing Chen & Ling Hu, 2017. "Systematic review and meta-analysis of traditional Chinese medicine in the treatment of constipation-predominant irritable bowel syndrome," PLOS ONE, Public Library of Science, vol. 12(12), pages 1-14, December.

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