IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0191646.html
   My bibliography  Save this article

Socio-economic status influences access to second-line disease modifying treatment in Relapsing Remitting Multiple Sclerosis patients

Author

Listed:
  • Floriane Calocer
  • Olivier Dejardin
  • Karine Droulon
  • Guy Launoy
  • Gilles Defer

Abstract

Objective: In MS, Socio-Economic status (SES) may influence healthcare and access to disease-modifying treatments (DMTs). Optimising delays to switch patients to a second-line DMT may hamper disease progression most effectively and achieve long term disease control. The objective of this study is to identify the influence of SES on the delay between first and second line DMT in RRMS patients, in Western-Normandy, France. Methods: The association between SES and the delay to access a second-line DMT were studied using data from the MS registry of Western-Normandy including 733 patients with a diagnosis of RRMS during the period in question [1982–2011]. We used the European Deprivation Index (EDI), a score with a rank level inversely related to SES. We performed multivariate adjusted Cox models for studying EDI effect on the delay between first and second line DMT. Results: No significant influence of SES was observed on delay to access a second-line DMT if first-line DMT exposure time was less than 5 years. After 5 years from initiation of first-line treatment the risk of accessing a second-line DMT is 3 times higher for patients with lower deprivation indices (1st quintile of EDI) ([HR] 3.14 95%CI [1.72–5.72], p-value

Suggested Citation

  • Floriane Calocer & Olivier Dejardin & Karine Droulon & Guy Launoy & Gilles Defer, 2018. "Socio-economic status influences access to second-line disease modifying treatment in Relapsing Remitting Multiple Sclerosis patients," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-12, February.
    • Handle: RePEc:plo:pone00:0191646
    DOI: 10.1371/journal.pone.0191646
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191646
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0191646&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0191646?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Krieger, N., 1992. "Overcoming the absence of socioeconomic data in medical records: Validation and application of a census-based methodology," American Journal of Public Health, American Public Health Association, vol. 82(5), pages 703-710.
    2. Trudy Owens & Nikos Evangelou & David Whynes, 2013. "Rationing and deprivation: disease-modifying therapies for multiple sclerosis in the United Kingdom," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 14(2), pages 315-321, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nan Zhang & Heng Xu, 2024. "Fairness of Ratemaking for Catastrophe Insurance: Lessons from Machine Learning," Information Systems Research, INFORMS, vol. 35(2), pages 469-488, June.
    2. Cots, Francesc & Mercade, Lluc & Castells, Xavier & Salvador, Xavier, 2004. "Relationship between hospital structural level and length of stay outliers: Implications for hospital payment systems," Health Policy, Elsevier, vol. 68(2), pages 159-168, May.
    3. Martin Gaechter & Peter Schwazer & Engelbert Theurl, 2012. "Stronger Sex but Earlier Death: A Multi-level Socioeconomic Analysis of Gender Differences in Mortality in Austria," DANUBE: Law and Economics Review, European Association Comenius - EACO, issue 1, pages 1-23, March.
    4. Michelle Sholzberg & Tara Gomes & David N Juurlink & Zhan Yao & Muhammad M Mamdani & Andreas Laupacis, 2016. "The Influence of Socioeconomic Status on Selection of Anticoagulation for Atrial Fibrillation," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-12, February.
    5. Schulz, Jan & Mayerhoffer, Daniel M., 2021. "A network approach to consumption," BERG Working Paper Series 173, Bamberg University, Bamberg Economic Research Group.
    6. Clarke, Christina A. & Miller, Tim & Chang, Ellen T. & Yin, Daixin & Cockburn, Myles & Gomez, Scarlett L., 2010. "Racial and social class gradients in life expectancy in contemporary California," Social Science & Medicine, Elsevier, vol. 70(9), pages 1373-1380, May.
    7. Allison C. Morgan & Nicholas LaBerge & Daniel B. Larremore & Mirta Galesic & Jennie E. Brand & Aaron Clauset, 2022. "Socioeconomic roots of academic faculty," Nature Human Behaviour, Nature, vol. 6(12), pages 1625-1633, December.
    8. Keyes, Katherine M. & March, Dana & Link, Bruce G. & Chilcoat, Howard D. & Susser, Ezra, 2013. "Do socio-economic gradients in smoking emerge differently across time by gender? Implications for the tobacco epidemic from a pregnancy cohort in California, USA," Social Science & Medicine, Elsevier, vol. 76(C), pages 101-106.
    9. Jinani Jayasekera & Eberechukwu Onukwugha & Christopher Cadham & Donna Harrington & Sarah Tom & Francoise Pradel & Michael Naslund, 2019. "An ecological approach to monitor geographic disparities in cancer outcomes," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-14, June.
    10. Justin Stoler & John R Weeks & Richard Appiah Otoo, 2013. "Drinking Water in Transition: A Multilevel Cross-sectional Analysis of Sachet Water Consumption in Accra," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-11, June.
    11. Michael Adjemian & Jeffrey Williams, 2009. "Using census aggregates to proxy for household characteristics: an application to vehicle ownership," Transportation, Springer, vol. 36(2), pages 223-241, March.
    12. Philibert, M.D. & Pampalon, R. & Hamel, D. & Thouez, J.-P. & Loiselle, C.G., 2007. "KW - Quebec: A local-scale evaluation system," Social Science & Medicine, Elsevier, vol. 64(8), pages 1651-1664, April.
    13. Masayoshi Oka, 2022. "Census-Tract-Level Median Household Income and Median Family Income Estimates: A Unidimensional Measure of Neighborhood Socioeconomic Status?," IJERPH, MDPI, vol. 20(1), pages 1-23, December.
    14. Stacey L Tannenbaum & Monique Hernandez & D Dandan Zheng & Daniel A Sussman & David J Lee, 2014. "Individual- and Neighborhood-Level Predictors of Mortality in Florida Colorectal Cancer Patients," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-10, August.
    15. Stafford, Mai & Duke-Williams, Oliver & Shelton, Nicola, 2008. "Small area inequalities in health: Are we underestimating them?," Social Science & Medicine, Elsevier, vol. 67(6), pages 891-899, September.
    16. M. Manos & Chanda Ho & Rosemary Murphy & Valentina Shvachko, 2013. "Physical, Social, and Psychological Consequences of Treatment for Hepatitis C," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 6(1), pages 23-34, March.
    17. Andrea S Gershon & Deva Thiruchelvam & Shawn Aaron & Matthew Stanbrook & Nicholas Vozoris & Wan C Tan & Eunice Cho & Teresa To, 2019. "Socioeconomic status (SES) and 30-day hospital readmissions for chronic obstructive pulmonary (COPD) disease: A population-based cohort study," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-16, May.
    18. Neugebauer Romain & Chandra Malini & Paredes Antonio & J. Graham David & McCloskey Carolyn & S. Go Alan, 2013. "A Marginal Structural Modeling Approach with Super Learning for a Study on Oral Bisphosphonate Therapy and Atrial Fibrillation," Journal of Causal Inference, De Gruyter, vol. 1(1), pages 21-50, June.
    19. Ping Yin & Lan Mu & Marguerite Madden & John Vena, 2014. "Hierarchical Bayesian modeling of spatio-temporal patterns of lung cancer incidence risk in Georgia, USA: 2000–2007," Journal of Geographical Systems, Springer, vol. 16(4), pages 387-407, October.
    20. Nathaniel Jembere & Michael A Campitelli & Morris Sherman & Jordan J Feld & Wendy Lou & Stuart Peacock & Eric Yoshida & Murray D Krahn & Craig Earle & Hla-Hla Thein, 2012. "Influence of Socioeconomic Status on Survival of Hepatocellular Carcinoma in the Ontario Population; A Population-Based Study, 1990–2009," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-10, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0191646. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.