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Agent-based modeling of the interaction between CD8+ T cells and Beta cells in type 1 diabetes

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  • Mustafa Cagdas Ozturk
  • Qian Xu
  • Ali Cinar

Abstract

We propose an agent-based model for the simulation of the autoimmune response in T1D. The model incorporates cell behavior from various rules derived from the current literature and is implemented on a high-performance computing system, which enables the simulation of a significant portion of the islets in the mouse pancreas. Simulation results indicate that the model is able to capture the trends that emerge during the progression of the autoimmunity. The multi-scale nature of the model enables definition of rules or equations that govern cellular or sub-cellular level phenomena and observation of the outcomes at the tissue scale. It is expected that such a model would facilitate in vivo clinical studies through rapid testing of hypotheses and planning of future experiments by providing insight into disease progression at different scales, some of which may not be obtained easily in clinical studies. Furthermore, the modular structure of the model simplifies tasks such as the addition of new cell types, and the definition or modification of different behaviors of the environment and the cells with ease.

Suggested Citation

  • Mustafa Cagdas Ozturk & Qian Xu & Ali Cinar, 2018. "Agent-based modeling of the interaction between CD8+ T cells and Beta cells in type 1 diabetes," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-21, January.
    • Handle: RePEc:plo:pone00:0190349
    DOI: 10.1371/journal.pone.0190349
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    References listed on IDEAS

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    1. Yuval Dor & Juliana Brown & Olga I. Martinez & Douglas A. Melton, 2004. "Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation," Nature, Nature, vol. 429(6987), pages 41-46, May.
    2. Jonathan Tang & C Anthony Hunt, 2010. "Identifying the Rules of Engagement Enabling Leukocyte Rolling, Activation, and Adhesion," PLOS Computational Biology, Public Library of Science, vol. 6(2), pages 1-15, February.
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