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Temporal dynamics of gene expression in heat-stressed Caenorhabditis elegans

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Listed:
  • Katharina Jovic
  • Mark G Sterken
  • Jacopo Grilli
  • Roel P J Bevers
  • Miriam Rodriguez
  • Joost A G Riksen
  • Stefano Allesina
  • Jan E Kammenga
  • L Basten Snoek

Abstract

There is considerable insight into pathways and genes associated with heat-stress conditions. Most genes involved in stress response have been identified using mutant screens or gene knockdowns. Yet, there is limited understanding of the temporal dynamics of global gene expression in stressful environments. Here, we studied global gene expression profiles during 12 hours of heat stress in the nematode C. elegans. Using a high-resolution time series of increasing stress exposures, we found a distinct shift in gene expression patterns between 3–4 hours into the stress response, separating an initially highly dynamic phase from a later relatively stagnant phase. This turning point in expression dynamics coincided with a phenotypic turning point, as shown by a strong decrease in movement, survival and, progeny count in the days following the stress. Both detectable at transcriptional and phenotypic level, this study pin-points a relatively small time frame during heat stress at which enough damage is accumulated, making it impossible to recover the next few days.

Suggested Citation

  • Katharina Jovic & Mark G Sterken & Jacopo Grilli & Roel P J Bevers & Miriam Rodriguez & Joost A G Riksen & Stefano Allesina & Jan E Kammenga & L Basten Snoek, 2017. "Temporal dynamics of gene expression in heat-stressed Caenorhabditis elegans," PLOS ONE, Public Library of Science, vol. 12(12), pages 1-16, December.
  • Handle: RePEc:plo:pone00:0189445
    DOI: 10.1371/journal.pone.0189445
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    1. Laura A. Herndon & Peter J. Schmeissner & Justyna M. Dudaronek & Paula A. Brown & Kristin M. Listner & Yuko Sakano & Marie C. Paupard & David H. Hall & Monica Driscoll, 2002. "Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans," Nature, Nature, vol. 419(6909), pages 808-814, October.
    2. Patrick D McMullen & Erin Z Aprison & Peter B Winter & Luis A N Amaral & Richard I Morimoto & Ilya Ruvinsky, 2012. "Macro-level Modeling of the Response of C. elegans Reproduction to Chronic Heat Stress," PLOS Computational Biology, Public Library of Science, vol. 8(1), pages 1-12, January.
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    Cited by:

    1. Fan Xu & Ruoyao Li & Erika D. Gromoff & Friedel Drepper & Bettina Knapp & Bettina Warscheid & Ralf Baumeister & Wenjing Qi, 2023. "Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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