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Blocks of chromosomes identical by descent in a population: Models and predictions

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  • Mathieu Tiret
  • Frédéric Hospital

Abstract

With the highly dense genomic data available nowadays, ignoring linkage between genes would result in a huge loss of information. One way to prevent such a loss is to focus on the blocks of chromosomes shared identical by descent (IBD) in populations. The development of the theoretical framework modelling IBD processes is essential to support the advent of new tools such as haplotype phasing, imputation, inferring population structure and demographic history, mapping loci or detecting signatures of selection. This article aims to present the relevant models used in this context, and specify the underlying definitions of identity by descent that are yet to be gathered at one place. In light of this, we derived a general expression for the expected IBD block length, for any population model at any generation after founding.

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  • Mathieu Tiret & Frédéric Hospital, 2017. "Blocks of chromosomes identical by descent in a population: Models and predictions," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-11, November.
    • Handle: RePEc:plo:pone00:0187416
    DOI: 10.1371/journal.pone.0187416
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    Cited by:

    1. Kerdoncuff, Elise & Lambert, Amaury & Achaz, Guillaume, 2020. "Testing for population decline using maximal linkage disequilibrium blocks," Theoretical Population Biology, Elsevier, vol. 134(C), pages 171-181.

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