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Do intra-articular hyaluronic acid injections delay total knee replacement in patients with osteoarthritis – A Cox model analysis

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  • Angélique Delbarre
  • Bernard Amor
  • Isabelle Bardoulat
  • Aymeric Tetafort
  • Nathalie Pelletier-Fleury

Abstract

Objectives: This study aimed to describe patients treated for knee osteoarthritis between 2006 and 2013 in France and to compare the delay from diagnosis to total knee replacement between patients who received intra-articular hyaluronic acid injections and those who did not receive the injections. A second objective was to compare direct medical costs for ambulatory care between treatment groups. Materials and methods: Patients were selected from a representative sample of the real world administrative claims database using an algorithm developed by experts from the scientific committee of the study. Data were matched with the medico-administrative database for hospital care. A Cox proportional hazards model was stratified for the treatment group and adjusted for available socio-demographic and medical covariates to compare restricted mean survival times at different time points (1, 3, 5 and 7.5 years) between groups. Costs were expressed in 2013 euros. Results: A total of 14,782 patients were treated for knee osteoarthritis (67% women; mean age = 68 years). Among this population, 1,662 patients had total knee replacement (11.2%). At each time point, restricted mean survival time without total knee replacement was significantly higher (p-values

Suggested Citation

  • Angélique Delbarre & Bernard Amor & Isabelle Bardoulat & Aymeric Tetafort & Nathalie Pelletier-Fleury, 2017. "Do intra-articular hyaluronic acid injections delay total knee replacement in patients with osteoarthritis – A Cox model analysis," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-19, November.
    • Handle: RePEc:plo:pone00:0187227
    DOI: 10.1371/journal.pone.0187227
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    1. Thierry Thomas & Françoise Amouroux & Patrice Vincent, 2017. "Intra articular hyaluronic acid in the management of knee osteoarthritis: Pharmaco-economic study from the perspective of the national health insurance system," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-17, March.
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