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Intra articular hyaluronic acid in the management of knee osteoarthritis: Pharmaco-economic study from the perspective of the national health insurance system

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  • Thierry Thomas
  • Françoise Amouroux
  • Patrice Vincent

Abstract

Introduction: Pharmaco-economic data on the management of knee osteoarthritis (OA) with intra articular hyaluronic acid (IA HA) viscosupplementation is limited. We contrasted IA HA with non-steroidal anti-inflammatory drugs (NSAIDs). Methods: Observational, prospective and multicenter study comparing treatments of knee OA costs and efficacy with either NSAIDs alone, or hyaluronic acid (Arthrum H 2%®), during a 6-month follow-up period. The investigators were pharmacists who recorded data on disease, drug consumption and healthcare circuit. Retrospectively, the 6-month period preceding inclusion was also studied, to ensure the comparability of groups. Results: 199 patients were analyzed in a NSAIDs group and 202 in an IA HA group. Any of the WOMAC sub-scores and the EQ-5D Quality of Life index were significantly improved in the IA HA group (p

Suggested Citation

  • Thierry Thomas & Françoise Amouroux & Patrice Vincent, 2017. "Intra articular hyaluronic acid in the management of knee osteoarthritis: Pharmaco-economic study from the perspective of the national health insurance system," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-17, March.
    • Handle: RePEc:plo:pone00:0173683
    DOI: 10.1371/journal.pone.0173683
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    1. Guccione, A.A. & Felson, D.T. & Anderson, J.J. & Anthony, J.M. & Zhang, Y. & Wilson, P.W.F. & Kelly-Hayes, M. & Wolf, P.A. & Kreger, B.E. & Kannel, W.B., 1994. "The effects of specific medical conditions on the functional limitations of elders in the Framingham study," American Journal of Public Health, American Public Health Association, vol. 84(3), pages 351-358.
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    1. Angélique Delbarre & Bernard Amor & Isabelle Bardoulat & Aymeric Tetafort & Nathalie Pelletier-Fleury, 2017. "Do intra-articular hyaluronic acid injections delay total knee replacement in patients with osteoarthritis – A Cox model analysis," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-19, November.

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