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Hypothyroidism as a risk factor for open angle glaucoma: A systematic review and meta-analysis

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  • Shiming Wang
  • Yue Liu
  • Guangying Zheng

Abstract

Purpose: The relationship between hypothyroidism and primary open angle glaucoma (POAG) has attracted intense interest recently, but the reported results have been controversial. This meta-analysis was carried out to determine the association between hypothyroidism and POAG. Methods: The literature was identified from three databases (Web of Science, Embase, and PubMed). The meta-analyses were performed using random-effects models, with results reported as adjusted odds ratios (ORs) with 95% confidence intervals (CI 95%). Results: A total of 11 studies meeting the inclusion criteria were included in the final meta-analysis. The pooled OR based on 11 risk estimates showed a statistically significant increased risk of POAG prevalence among individuals with hypothyroidism (OR = 1.64, 95% CI = 1.27–2.13). Substantial heterogeneity among these studies was detected (P

Suggested Citation

  • Shiming Wang & Yue Liu & Guangying Zheng, 2017. "Hypothyroidism as a risk factor for open angle glaucoma: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-13, October.
    • Handle: RePEc:plo:pone00:0186634
    DOI: 10.1371/journal.pone.0186634
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    References listed on IDEAS

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    1. Minwen Zhou & Wei Wang & Wenbin Huang & Xiulan Zhang, 2014. "Diabetes Mellitus as a Risk Factor for Open-Angle Glaucoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-9, August.
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