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Prognostic value of SRSF2 mutations in patients with de novo myelodysplastic syndromes: A meta-analysis

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  • Xue Zheng
  • Zhi Zhan
  • Duolan Naren
  • Jing Li
  • Tianyou Yan
  • Yuping Gong

Abstract

Background: The recent application of gene-sequencing technology has identified many new somatic mutations in patients with myelodysplastic syndromes (MDS). Among them, serine and arginine rich splicing factor 2 (SRSF2) mutations belonging to the RNA splicing pathway were of interest. Many studies have already reported the potential prognostic value of SRSF2 mutations in MDS patients, with controversial results. Therefore, a meta-analysis was performed to investigate their prognostic impact on MDS. Methods: Databases, including PubMed, Embase and the Cochrane Library, were searched for relevant studies published up to 14 October 2016. Overall survival (OS) was selected as the primary endpoint, and acute myeloid leukemia (AML) transformation was the secondary endpoint. We extracted the corresponding hazard ratios (HRs) and their 95% confidence intervals (CIs) for OS and AML transformation from multivariate Cox proportional hazards models. The combined HRs with their 95% CIs were calculated using fixed or random effect models. Results: A total of 10 cohort studies, covering 1864 patients with de novo MDS and 294 patients with SRSF2 mutations, were included in the final meta-analysis. Our results indicated that SRSF2 mutations had an adverse prognostic impact on OS (p

Suggested Citation

  • Xue Zheng & Zhi Zhan & Duolan Naren & Jing Li & Tianyou Yan & Yuping Gong, 2017. "Prognostic value of SRSF2 mutations in patients with de novo myelodysplastic syndromes: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-12, September.
    • Handle: RePEc:plo:pone00:0185053
    DOI: 10.1371/journal.pone.0185053
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    References listed on IDEAS

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    1. Jiang Lin & Jing Yang & Xiang-mei Wen & Lei Yang & Zhao-qun Deng & Zhen Qian & Ji-chun Ma & Hong Guo & Ying-ying Zhang & Wei Qian & Jun Qian, 2014. "Detection of SRSF2-P95 Mutation by High-Resolution Melting Curve Analysis and Its Effect on Prognosis in Myelodysplastic Syndrome," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-12, December.
    2. Kim, Jaehoon & Kim, Sangsin, 2015. "2012년 국회법 개정의 효과 연구 [A Study on the Effect of the 2012 National Assembly Act Amendment]," KDI Research Monographs, Korea Development Institute (KDI), volume 127, number v:2015-03(k):y:2015:p:1-1.
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