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Role of classic signs as diagnostic predictors for enteric fever among returned travellers: Relative bradycardia and eosinopenia

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  • Takashi Matono
  • Satoshi Kutsuna
  • Yasuyuki Kato
  • Yuichi Katanami
  • Kei Yamamoto
  • Nozomi Takeshita
  • Kayoko Hayakawa
  • Shuzo Kanagawa
  • Mitsuo Kaku
  • Norio Ohmagari

Abstract

Background: The lack of characteristic clinical findings and accurate diagnostic tools has made the diagnosis of enteric fever difficult. We evaluated the classic signs of relative bradycardia and eosinopenia as diagnostic predictors for enteric fever among travellers who had returned from the tropics or subtropics. Methods: This matched case-control study used data from 2006 to 2015 for culture-proven enteric fever patients as cases. Febrile patients (>38.3°C) with non-enteric fever, who had returned from the tropics or subtropics, were matched to the cases in a 1:3 ratio by age (±3 years), sex, and year of diagnosis as controls. Cunha’s criteria were used for relative bradycardia. Absolute eosinopenia was defined as an eosinophilic count of 0/μL. Results: Data from 160 patients (40 cases and 120 controls) were analysed. Cases predominantly returned from South Asia (70% versus 18%, p

Suggested Citation

  • Takashi Matono & Satoshi Kutsuna & Yasuyuki Kato & Yuichi Katanami & Kei Yamamoto & Nozomi Takeshita & Kayoko Hayakawa & Shuzo Kanagawa & Mitsuo Kaku & Norio Ohmagari, 2017. "Role of classic signs as diagnostic predictors for enteric fever among returned travellers: Relative bradycardia and eosinopenia," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-12, June.
    • Handle: RePEc:plo:pone00:0179814
    DOI: 10.1371/journal.pone.0179814
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    Cited by:

    1. Narcisa Muresu & Giovanni Sotgiu & Bianca Maria Are & Andrea Cossu & Clementina Cocuzza & Marianna Martinelli & Sergio Babudieri & Riccardo Are & Marco Dettori & Antonio Azara & Laura Saderi & Andrea , 2020. "Travel-Related Typhoid Fever: Narrative Review of the Scientific Literature," IJERPH, MDPI, vol. 17(2), pages 1-12, January.

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