IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0177113.html
   My bibliography  Save this article

Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: A systematic review and meta-analysis

Author

Listed:
  • Evelyn Balsells
  • Laurence Guillot
  • Harish Nair
  • Moe H Kyaw

Abstract

Background: Routine immunisation with pneumococcal conjugate vaccines (PCV7/10/13) has reduced invasive pneumococcal disease (IPD) due to vaccine serotypes significantly. However, an increase in disease due to non-vaccine types, or serotype replacement, has been observed. Serotypes’ individual contributions to IPD play a critical role in determining the overall effects of PCVs. This study examines the distribution of pneumococcal serotypes in children to identify leading serotypes associated with IPD post-PCV introduction. Methods: A systematic search was performed to identify studies and surveillance reports (published between 2000 and December 2015) of pneumococcal serotypes causing childhood IPD post-PCV introduction. Serotype data were differentiated based on the PCV administered during the study period: PCV7 or higher valent PCVs (PCV10 or PCV13). Meta-analysis was conducted to estimate the proportional contributions of the most frequent serotypes in childhood IPD in each period. Results: We identified 68 studies reporting serotype data among IPD cases in children. We analysed data from 38 studies (14 countries) where PCV7 was administered and 20 (24 countries) where PCV10 or PCV13 have been introduced. Studies reported early and late periods of PCV7 administration (range: 2001∓13). In these settings, serotype 19A was the most predominant cause of childhood IPD, accounting for 21.8% (95%CI 18.6∓25.6) of cases. In countries that have introduced higher valent PCVs, study periods were largely representative of the transition and early years of PCV10 or PCV13. In these studies, the overall serotype-specific contribution of 19A was lower (14.2% 95%CI 11.1∓18.3). Overall, non-PCV13 serotypes contributed to 42.2% (95%CI 36.1∓49.5%) of childhood IPD cases. However, regional differences were noted (57.8% in North America, 71.9% in Europe, 45.9% in Western Pacific, 28.5% in Latin America, 42.7% in one African country, and 9.2% in one Eastern Mediterranean country). Predominant non-PCV13 serotypes overall were 22F, 12F, 33F, 24F, 15C, 15B, 23B, 10A, and 38 (descending order), but their rank order varied by region. Conclusion: Childhood IPD is associated with a wide number of serotypes. In the early years after introduction of higher valent PCVs, non-PCV13 types caused a considerable proportion of childhood IPD. Serotype data, particularly from resource-limited countries with high burden of IPD, are needed to assess the importance of serotypes in different settings. The geographic diversity of pneumococcal serotypes highlights the importance of continued surveillance to guide vaccine design and recommendations.

Suggested Citation

  • Evelyn Balsells & Laurence Guillot & Harish Nair & Moe H Kyaw, 2017. "Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-20, May.
    • Handle: RePEc:plo:pone00:0177113
    DOI: 10.1371/journal.pone.0177113
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177113
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0177113&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0177113?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Antony Young, 2014. "1 + 1 = 3," Palgrave Macmillan Books, in: Brand Media Strategy, edition 0, chapter 0, pages 81-99, Palgrave Macmillan.
    2. Christopher May, 2017. ": 40 years on," Third World Quarterly, Taylor & Francis Journals, vol. 38(10), pages 2223-2241, October.
    3. Daniel R Feikin & Eunice W Kagucia & Jennifer D Loo & Ruth Link-Gelles & Milo A Puhan & Thomas Cherian & Orin S Levine & Cynthia G Whitney & Katherine L O’Brien & Matthew R Moore & the Serotype Replac, 2013. "Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites," PLOS Medicine, Public Library of Science, vol. 10(9), pages 1-28, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Peter Francis Raguindin, 2020. "The changing epidemiology of pneumococcal diseases: new challenges after widespread routine immunization," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 65(6), pages 709-710, July.
    2. Peter Francis Raguindin, 0. "The changing epidemiology of pneumococcal diseases: new challenges after widespread routine immunization," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 0, pages 1-2.
    3. Kadi J. Horn & Melissa A. Schopper & Zoe G. Drigot & Sarah E. Clark, 2022. "Airway Prevotella promote TLR2-dependent neutrophil activation and rapid clearance of Streptococcus pneumoniae from the lung," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Uri Obolski & Todd D. Swarthout & Akuzike Kalizang’oma & Thandie S. Mwalukomo & Jia Mun Chan & Caroline M. Weight & Comfort Brown & Rory Cave & Jen Cornick & Arox Wadson Kamng’ona & Jacquline Msefula , 2023. "The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jonas Boone & Johannes Derboven & Sarah Kuypers & Francesco Figari & Gerlinde Verbist, 2019. "EWIGE 2 Update and Extension of the EUROMOD Wealth Taxation Project," JRC Working Papers on Taxation & Structural Reforms 2019-07, Joint Research Centre.
    2. Jenny Saxton & Simone N Rodda & Natalia Booth & Stephanie S Merkouris & Nicki A Dowling, 2021. "The efficacy of Personalized Normative Feedback interventions across addictions: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-31, April.
    3. Shikuo Chen & Chenhui Wei & Tianhong Yang & Wancheng Zhu & Honglei Liu & Pathegama Gamage Ranjith, 2018. "Three-Dimensional Numerical Investigation of Coupled Flow-Stress-Damage Failure Process in Heterogeneous Poroelastic Rocks," Energies, MDPI, vol. 11(8), pages 1-16, July.
    4. Nadia Zrelli & Imene Berguiga & Ali Abdallah & Philippe Adair, 2017. "Risques spécifiques et profitabilité des banques islamiques en région MENA," Post-Print hal-01667423, HAL.
    5. Yehui Tong & Zelia Serrasqueiro, 2020. "The Influential Factors on Capital Structure: A Study on Portuguese High Technology and Medium-High Technology Small and Medium-Sized Enterprises," International Journal of Financial Research, International Journal of Financial Research, Sciedu Press, vol. 11(4), pages 23-35, July.
    6. Pelly, Diane & Daly, Michael & Delaney, Liam & Doyle, Orla, 2022. "Worker stress, burnout, and wellbeing before and during the COVID-19 restrictions in the United Kingdom," LSE Research Online Documents on Economics 115098, London School of Economics and Political Science, LSE Library.
    7. Francine D. Blau & Anne E. Winkler, 2017. "Women, Work, and Family," NBER Working Papers 23644, National Bureau of Economic Research, Inc.
    8. Evgenia Anastasiou & Georgia Anagnostou & George Theodossiou & Vasileios Papamargaritis, 2020. "Physicians' Brain Drain: Investigating the Determinants to Emigrate Through Empirical Evidence," International Journal of Business and Economic Sciences Applied Research (IJBESAR), International Hellenic University (IHU), Kavala Campus, Greece (formerly Eastern Macedonia and Thrace Institute of Technology - EMaTTech), vol. 13(2), pages 83-92, September.
    9. Gervais, Antoine & Jensen, J. Bradford, 2019. "The tradability of services: Geographic concentration and trade costs," Journal of International Economics, Elsevier, vol. 118(C), pages 331-350.
    10. Irit Keynan & Alon Lazar, 2017. "Defining the Good Citizen: Online Conceptions of American Members of the Yahoo! Answers Community," International Journal of Social Science Studies, Redfame publishing, vol. 5(4), pages 6-13, April.
    11. Harsman Tandilittin, 2016. "What should the Government do to Stop Epidemic of Smoking among Teenagers in Indonesia?," Asian Culture and History, Canadian Center of Science and Education, vol. 8(1), pages 140-140, March.
    12. Yuzhao Chen & Jie Ma, 2016. "Observation and Reflection on the Dispute of Delaying Retirement Policy in China," Asian Social Science, Canadian Center of Science and Education, vol. 12(10), pages 190-190, October.
    13. Götz Marta & Jankowska Barbara, 2016. "Internationalization by State-owned Enterprises (SOEs) and Sovereign Wealth Funds (SWFs) after the 2008 Crisis. Looking for Generalizations," International Journal of Management and Economics, Warsaw School of Economics, Collegium of World Economy, vol. 50(1), pages 63-81, June.
    14. Daniel Parnell & Andy Pringle & Paul Widdop & Stephen Zwolinsky, 2015. "Understanding Football as a Vehicle for Enhancing Social Inclusion: Using an Intervention Mapping Framework," Social Inclusion, Cogitatio Press, vol. 3(3), pages 158-166.
    15. Valtteri Arstila & Alexandra L Georgescu & Henri Pesonen & Daniel Lunn & Valdas Noreika & Christine M Falter-Wagner, 2020. "Event timing in human vision: Modulating factors and independent functions," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-22, August.
    16. Lawrence Mundia, 2020. "A Descriptive Profile of Selected Brunei Convicts: Viewpoint," Journal of Public Administration and Governance, Macrothink Institute, vol. 10(3), pages 619-619, December.
    17. Darko Dukic & Brent McDonald & Ramón Spaaij, 2017. "Being Able to Play: Experiences of Social Inclusion and Exclusion Within a Football Team of People Seeking Asylum," Social Inclusion, Cogitatio Press, vol. 5(2), pages 101-110.
    18. Ahmet Kurnaz, 2018. "Examining Effects of Mathematical Problem-Solving, Mathematical Reasoning and Spatial Abilities on Gifted Students’ Mathematics Achievement," World Scientific Research, Asian Online Journal Publishing Group, vol. 5(1), pages 37-43.
    19. Lisa Kastner, 2017. "From Outsiders to Insiders: A Civil Society Perspective on EU Financial Reforms," Post-Print hal-02184200, HAL.
    20. Sinclair Davidson & Ashton de Silva, 2014. "The Plain Truth about Plain Packaging: An Econometric Analysis of the Australian 2011 Tobacco Plain Packaging Act," Agenda - A Journal of Policy Analysis and Reform, Australian National University, College of Business and Economics, School of Economics, vol. 21(1), pages 27-44.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0177113. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.