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A combination of baseline plasma immune markers can predict therapeutic response in multidrug resistant tuberculosis

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  • Selena Ferrian
  • Claudia Manca
  • Sugnet Lubbe
  • Francesca Conradie
  • Nazir Ismail
  • Gilla Kaplan
  • Clive M Gray
  • Dorothy Fallows

Abstract

Objective: To identify plasma markers predictive of therapeutic response in patients with multidrug resistant tuberculosis (MDR-TB). Methods: Fifty HIV-negative patients with active pulmonary MDR-TB were analysed for six soluble analytes in plasma at the time of initiating treatment (baseline) and over six months thereafter. Patients were identified as sputum culture positive or negative at baseline. Culture positive patients were further stratified by the median time to sputum culture conversion (SCC) as fast responders (

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  • Selena Ferrian & Claudia Manca & Sugnet Lubbe & Francesca Conradie & Nazir Ismail & Gilla Kaplan & Clive M Gray & Dorothy Fallows, 2017. "A combination of baseline plasma immune markers can predict therapeutic response in multidrug resistant tuberculosis," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0176660
    DOI: 10.1371/journal.pone.0176660
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    1. Catherine Riou & Blas Perez Peixoto & Lindi Roberts & Katharina Ronacher & Gerhard Walzl & Claudia Manca & Roxana Rustomjee & Thuli Mthiyane & Dorothy Fallows & Clive M Gray & Gilla Kaplan, 2012. "Effect of Standard Tuberculosis Treatment on Plasma Cytokine Levels in Patients with Active Pulmonary Tuberculosis," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-12, May.
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    1. Murilo Sena Amaral & Daisy Woellner Santos & Adriana S. A. Pereira & Ana Carolina Tahira & João V. M. Malvezzi & Patrícia Aoki Miyasato & Rafaela de Paula Freitas & Jorge Kalil & Elisa M. Tjon Kon Fat, 2021. "Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

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