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Effect of Standard Tuberculosis Treatment on Plasma Cytokine Levels in Patients with Active Pulmonary Tuberculosis

Author

Listed:
  • Catherine Riou
  • Blas Perez Peixoto
  • Lindi Roberts
  • Katharina Ronacher
  • Gerhard Walzl
  • Claudia Manca
  • Roxana Rustomjee
  • Thuli Mthiyane
  • Dorothy Fallows
  • Clive M Gray
  • Gilla Kaplan

Abstract

Background: Sputum Mycobacterium tuberculosis (Mtb) culture is commonly used to assess response to antibiotic treatment in individuals with pulmonary tuberculosis (TB). Such techniques are constrained by the slow growth rate of Mtb, and more sensitive methods to monitor Mtb clearance are needed. The goal of this study was to evaluate changes in plasma cytokines in patients undergoing treatment for TB as a means of identifying candidate host markers associated with microbiologic response to therapy. Methods: Twenty-four plasma cytokines/chemokines were measured in 42 individuals diagnosed with active pulmonary TB, 52% were HIV co-infected. Individuals, undergoing a 26-week standard TB treatment, were followed longitudinally over 18 months and measurements were associated with HIV status and rates of sputum culture conversion. Results: Plasma concentrations of interferon-inducible protein-10 (IP-10) and vascular endothelial growth factor (VEGF) were significantly reduced upon TB treatment, regardless of HIV status. By the end of treatment, IP-10 concentrations were significantly lower in HIV negative individuals when compared to HIV-positive individuals (p = 0.02). Moreover, in HIV negative patients, plasma VEGF concentrations, measured as early as 2-weeks post TB treatment initiation, positively correlated with the time of sputum conversion (p = 0.0017). No significant changes were observed in other studied immune mediators. Conclusions: These data suggest that VEGF plasma concentration, measured during early TB treatment, could represent a surrogate marker to monitor sputum culture conversion in HIV uninfected individuals.

Suggested Citation

  • Catherine Riou & Blas Perez Peixoto & Lindi Roberts & Katharina Ronacher & Gerhard Walzl & Claudia Manca & Roxana Rustomjee & Thuli Mthiyane & Dorothy Fallows & Clive M Gray & Gilla Kaplan, 2012. "Effect of Standard Tuberculosis Treatment on Plasma Cytokine Levels in Patients with Active Pulmonary Tuberculosis," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0036886
    DOI: 10.1371/journal.pone.0036886
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    Cited by:

    1. Stefanie Krug & Manish Gupta & Pankaj Kumar & Laine Feller & Elizabeth A. Ihms & Bong Gu Kang & Geetha Srikrishna & Ted M. Dawson & Valina L. Dawson & William R. Bishai, 2023. "Inhibition of host PARP1 contributes to the anti-inflammatory and antitubercular activity of pyrazinamide," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Selena Ferrian & Claudia Manca & Sugnet Lubbe & Francesca Conradie & Nazir Ismail & Gilla Kaplan & Clive M Gray & Dorothy Fallows, 2017. "A combination of baseline plasma immune markers can predict therapeutic response in multidrug resistant tuberculosis," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-15, May.

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