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Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis

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  • Jinhua Zhang
  • Xudong Sun
  • Jiemin Wang
  • Fuhua Zhang
  • Xiaohua Li
  • Jian Han

Abstract

The aim of this study was to clarify the association of IL-1RN variable number of tandem repeat (VNTR) polymorphism and H. pylori infection. We performed a meta-analysis of studies retrieved by systematic searches of Pubmed, Embase and the Cochrane Library. Data were analyzed with STATA 13.1 using pooled odds ratios (ORs) with 95% confidence intervals (CIs). A total of 18 studies were included in our meta-analysis, and IL-1RN VNTR was found to be significantly associated with H. pylori infection in the comparisons of 22+2L vs. LL (OR = 1.17, 95% CI = 1.02–1.33) and 2 allele vs. L allele (OR = 1.18, 95% CI = 1.00–1.40). Stratified analyses on study designs and ethnicities were also conducted. IL-1RN VNTR was positively correlated with H. pylori infection in Asian subgroup and Hospital-Based subgroup (i.e., study samples obtained from hospital inpatients). In conclusion, our study demonstrated that IL-1RN VNTR polymorphism might increase the risk of H. pylori infection, especially in Asians.

Suggested Citation

  • Jinhua Zhang & Xudong Sun & Jiemin Wang & Fuhua Zhang & Xiaohua Li & Jian Han, 2017. "Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-12, April.
    • Handle: RePEc:plo:pone00:0175052
    DOI: 10.1371/journal.pone.0175052
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    References listed on IDEAS

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    1. Ying Zhang & Changming Liu & Huiping Peng & Jianzhi Zhang & Quanlin Feng, 2012. "IL1 Receptor Antagonist Gene IL1-RN Variable Number of Tandem Repeats Polymorphism and Cancer Risk: A Literature Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    2. Xudong Sun & Yuanyuan Xu & Li Wang & Fuhua Zhang & Jinhua Zhang & Ximei Fu & Tao Jing & Jian Han, 2016. "Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-12, January.
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