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Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis

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  • Xudong Sun
  • Yuanyuan Xu
  • Li Wang
  • Fuhua Zhang
  • Jinhua Zhang
  • Ximei Fu
  • Tao Jing
  • Jian Han

Abstract

Background: Several host genetic factors are thought to affect susceptibility to Helicobacter pylori infection-related diseases, including tumor necrosis factor (TNF)-α. Previous studies have evaluated the association between TNFA gene polymorphisms and H. pylori infection, but the results were inconclusive. We conducted this meta-analysis to clarify the association between TNFA polymorphisms and H. pylori infection. Methods: Published literature within PubMed, Embase, and the Cochrane Library were used in our meta-analysis. Data were analyzed with the Stata13.1 software package using pooled odds ratios (ORs) with 95% confidence intervals (CI). Results: A total of 24 studies were included in our study. The TNFA -308G>A polymorphism was associated with decreasing H. pylori infection (AA vs. AG+GG, OR = 0.64, 95% CI = 0.43–0.97; AA vs. GG, OR = 0.64, 95% CI = 0.43–0.97). A significantly decreased risk was also found for -1031T>C polymorphism (CC vs. CT+TT, OR = 0.61, 95% CI = 0.44–0.84). -863C>A polymorphism was associated with increasing risk of H. pylori infection (AA+AC vs. CC, OR = 1.47, 95% CI = 1.16–1.86; A allele vs. C allele, OR = 1.40, 95% CI = 1.14–1.72). There was no significant association between -857C>T polymorphism and H. pylori infection. When stratified analysis was conducted on H. pylori infection detection methods, -857C>T and -863C>A polymorphisms were associated with H. pylori infection for the non-ELISA subgroup. When stratified for ethnicity or study design, -863C>A significantly increased the risk and -1031T>C decreased the risk for the Asian subgroup and hospital-based subgroup. Conclusion: Results of our meta-analysis demonstrate that TNFA -308G>A and -1031 T>C polymorphisms may be protective factors against H. pylori infection, and -863C>A may be a risk factor, especially in Asian populations. Further studies with larger sample sizes are required to validate these results.

Suggested Citation

  • Xudong Sun & Yuanyuan Xu & Li Wang & Fuhua Zhang & Jinhua Zhang & Ximei Fu & Tao Jing & Jian Han, 2016. "Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-12, January.
    • Handle: RePEc:plo:pone00:0147410
    DOI: 10.1371/journal.pone.0147410
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    References listed on IDEAS

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    1. Bei-Bei Zhang & Xing-Zhen Liu & Jin Sun & Yan-Wei Yin & Qian-Qian Sun, 2013. "Association between TNF α Gene Polymorphisms and the Risk of Duodenal Ulcer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-7, February.
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    1. Jinhua Zhang & Xudong Sun & Jiemin Wang & Fuhua Zhang & Xiaohua Li & Jian Han, 2017. "Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-12, April.

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