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Gamma-glutamyltransferase and risk of cardiovascular mortality: A dose-response meta-analysis of prospective cohort studies

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  • Junna Wang
  • Dandan Zhang
  • Rongzhong Huang
  • Xingsheng Li
  • Wenxiang Huang

Abstract

Background: Serum gamma-glutamyltransferase (GGT) elevation likely contributes to cardiovascular (CV) mortality, however it has remained unknown whether a dose-response relationship exists between serum GGT and CV mortality. Methods: We searched the PubMed, EMBASE, and Cochrane library databases for prospective cohort studies published up to October 2, 2016. Summary hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) were calculated using a fixed effects model. Findings: Nine prospective studies, including 527,589 participants and more than 7,011 cases, were included in this meta-analysis. For the moderate, high, and highest levels of GGT, the pooled HRs of CV mortality were 1.11 (95% CI = 1.04–1.19), 1.29 (95% CI = 1.21–1.38) and 1.59 (95% CI = 1.47–1.72), respectively (all p

Suggested Citation

  • Junna Wang & Dandan Zhang & Rongzhong Huang & Xingsheng Li & Wenxiang Huang, 2017. "Gamma-glutamyltransferase and risk of cardiovascular mortality: A dose-response meta-analysis of prospective cohort studies," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-19, February.
    • Handle: RePEc:plo:pone00:0172631
    DOI: 10.1371/journal.pone.0172631
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