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Complex Association between Alanine Aminotransferase Activity and Mortality in General Population: A Systematic Review and Meta-Analysis of Prospective Studies

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  • Zhengtao Liu
  • Huaijun Ning
  • Shuping Que
  • Linlin Wang
  • Xue Qin
  • Tao Peng

Abstract

Objective: Controversy exists in using alanine aminotransferase (ALT) activity for predicting long-term survival. Therefore, this research study investigated the association between ALT activity and mortality through a systematic review and meta-analysis of previous prospective studies. Methods: Electronic literature databases, including PubMed, Embase, and the Institute for Scientific Information (ISI), were searched for relevant prospective observational studies (published before Dec 30, 2013) on the association between baseline ALT activity and ensuing all-cause/disease-specific mortality. Information on nationality, sample size, participant characteristics, follow-up duration, comparison, outcome assessment, hazard ratios (HRs) and adjusted covariates was extracted. Pooled HRs and corresponding 95% confidence intervals (CIs) were separately calculated for categorical risk estimates (highest vs. lowest ALT categories) and continuous risk estimates (per 5 U/l of ALT increment) in subgroups separated by age (

Suggested Citation

  • Zhengtao Liu & Huaijun Ning & Shuping Que & Linlin Wang & Xue Qin & Tao Peng, 2014. "Complex Association between Alanine Aminotransferase Activity and Mortality in General Population: A Systematic Review and Meta-Analysis of Prospective Studies," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-19, March.
    • Handle: RePEc:plo:pone00:0091410
    DOI: 10.1371/journal.pone.0091410
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    References listed on IDEAS

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    2. Zhengtao Liu & Shuping Que & Huaijun Ning & Linlin Wang & Tao Peng, 2013. "Elevated Alanine Aminotransferase Is Strongly Associated with Incident Metabolic Syndrome: A Meta-Analysis of Prospective Studies," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-11, December.
    3. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    Cited by:

    1. Sang Joon An & Yun-Jung Yang & Na-mo Jeon & Yeon-Pyo Hong & Yeong In Kim & Doo-Young Kim, 2021. "Significantly Reduced Alanine Aminotransferase Level Increases All-Cause Mortality Rate in the Elderly after Ischemic Stroke," IJERPH, MDPI, vol. 18(9), pages 1-10, May.

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