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Identifying radiation-induced survivorship syndromes affecting bowel health in a cohort of gynecological cancer survivors

Author

Listed:
  • Gunnar Steineck
  • Viktor Skokic
  • Fei Sjöberg
  • Cecilia Bull
  • Eleftheria Alevronta
  • Gail Dunberger
  • Karin Bergmark
  • Ulrica Wilderäng
  • Jung Hun Oh
  • Joseph O Deasy
  • Rebecka Jörnsten

Abstract

Background: During radiotherapy unwanted radiation to normal tissue surrounding the tumor triggers survivorship diseases; we lack a nosology for radiation-induced survivorship diseases that decrease bowel health and we do not know which symptoms are related to which diseases. Methods: Gynecological-cancer survivors were followed-up two to 15 years after having undergone radiotherapy; they reported in a postal questionnaire the frequency of 28 different symptoms related to bowel health. Population-based controls gave the same information. With a modified factor analysis, we determined the optimal number of factors, factor loadings for each symptom, factor-specific factor-loading cutoffs and factor scores. Results: Altogether data from 623 survivors and 344 population-based controls were analyzed. Six factors best explain the correlation structure of the symptoms; for five of these a statistically significant difference (P

Suggested Citation

  • Gunnar Steineck & Viktor Skokic & Fei Sjöberg & Cecilia Bull & Eleftheria Alevronta & Gail Dunberger & Karin Bergmark & Ulrica Wilderäng & Jung Hun Oh & Joseph O Deasy & Rebecka Jörnsten, 2017. "Identifying radiation-induced survivorship syndromes affecting bowel health in a cohort of gynecological cancer survivors," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-15, February.
    • Handle: RePEc:plo:pone00:0171461
    DOI: 10.1371/journal.pone.0171461
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    References listed on IDEAS

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    1. Henry Kaiser, 1958. "The varimax criterion for analytic rotation in factor analysis," Psychometrika, Springer;The Psychometric Society, vol. 23(3), pages 187-200, September.
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    1. Ragnhild Johanne Tveit Sekse & Gail Dunberger & Mette Linnet Olesen & Maria Østerbye & Lene Seibæk, 2019. "Lived experiences and quality of life after gynaecological cancer—An integrative review," Journal of Clinical Nursing, John Wiley & Sons, vol. 28(9-10), pages 1393-1421, May.

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