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Expanded antiretroviral treatment, sexual networks, and condom use: Treatment as prevention unlikely to succeed without partner reduction among men who have sex with men in China

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Listed:
  • Jie Lou
  • Peipei Hu
  • Han-Zhu Qian
  • Yuhua Ruan
  • Zhen Jin
  • Hui Xing
  • Yiming Shao
  • Sten H Vermund

Abstract

Background: To project the impact of partner reduction on preventing new HIV infections among men who have sex with men (MSM) under varying conditions of enhanced HIV testing and treatment (T&T) and condom use in Beijing, China. Methods and findings: A complex network model was fitted to predict the number of new HIV infections averted from 2014 to 2023 under four scenarios of sexual behavior risk reduction (S)—S1: Male sexual partners decrease (reduced by a random value m from 1–50) while condom use increases (risk constant p is a random value between 0.2 and 1]); S2: Both sexual partners and condom use decrease (m 1, 50; p 1, 1.8); S3: Sexual partners reduce (m 1, 10) while condom use increases or decreases (p 0.2, 1.8); S4: Only MSM with ≥100 male sexual partners reduce their partners (m 1, 50) while condom use increases (p 0.2, 1). Conclusion: Partner reduction is a vital factor within HIV combination interventions to reduce HIV incidence among Beijing MSM, with substantial additional benefits derived from condom use. T&T without substantial partner reduction and increased condom use is less promising unless its implementation were extremely (and improbably) efficient.

Suggested Citation

  • Jie Lou & Peipei Hu & Han-Zhu Qian & Yuhua Ruan & Zhen Jin & Hui Xing & Yiming Shao & Sten H Vermund, 2017. "Expanded antiretroviral treatment, sexual networks, and condom use: Treatment as prevention unlikely to succeed without partner reduction among men who have sex with men in China," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-18, April.
  • Handle: RePEc:plo:pone00:0171295
    DOI: 10.1371/journal.pone.0171295
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    References listed on IDEAS

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    1. Lin Lu & Manhong Jia & Yanling Ma & Li Yang & Zhiwei Chen & David D. Ho & Yan Jiang & Linqi Zhang, 2008. "The changing face of HIV in China," Nature, Nature, vol. 455(7213), pages 609-611, October.
    2. Hong-Min Li & Rui-Rui Peng & Jing Li & Yue-Ping Yin & Baoxi Wang & Myron S Cohen & Xiang-Sheng Chen, 2011. "HIV Incidence among Men Who Have Sex with Men in China: A Meta-Analysis of Published Studies," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-8, August.
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