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Evidence That HIV-1 CRF01_AE Is Associated with Low CD4+T Cell Count and CXCR4 Co-Receptor Usage in Recently Infected Young Men Who Have Sex with Men (MSM) in Shanghai, China

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Listed:
  • Xiaoshan Li
  • Yile Xue
  • Leiming Zhou
  • Yi Lin
  • Xiaolei Yu
  • Xuqin Wang
  • Xiaohong Zhen
  • Wei Zhang
  • Zhen Ning
  • Qing Yue
  • Jie Fu
  • Fangwei Shen
  • Jing Gai
  • Yuqing Xu
  • Jiawen Mao
  • Xianming Gao
  • Xiaopei Shen
  • Laiyi Kang
  • Guido Vanham
  • Hua Cheng
  • Ying Wang
  • Minghua Zhuang
  • Xun Zhuang
  • Qichao Pan
  • Ping Zhong

Abstract

Men who have sex with men (MSM) have recently accounted for an alarmingly increasing proportion of HIV-1 transmission in China. In order to investigate the immune status as a result of CRF01_AE infection and CXCR4 co-receptor usage in a young Shanghai-based HIV-1-infected MSM population in Shanghai, 364 HIV-1-infected MSM with average age of 22.7 years old, newly diagnosed between Jan 2009 and Jul 2013 were analyzed for CD4+T cell count, subtyping using phylogenetic analysis, and viral co-receptor tropism using Geno2pheno and webPSSM in combination. A total of 276 individuals were identified as recently infected. Subtype assignment were as follows: 176 (63.8%) CRF01_AE, 77 (27.9%) CRF07_BC, and 23 (8.3%) subtype B. Besides, 24 second-generation recombinant strains were identified. A lower CD4+T cell count at baseline survey was observed among CRF01_AE strain-infected individuals, compared to those who were infected with CRF07_BC (P 500 lower in CRF01_AE infection than CRF07_BC infection. It is worth noting that 32.4%–40.9% of CRF01_AE strain-infected individuals were predicted to carry CXCR4-tropic viruses whereas none of CRF07_BC and subtype B were found to be as CXCR4-tropic viruses (P

Suggested Citation

  • Xiaoshan Li & Yile Xue & Leiming Zhou & Yi Lin & Xiaolei Yu & Xuqin Wang & Xiaohong Zhen & Wei Zhang & Zhen Ning & Qing Yue & Jie Fu & Fangwei Shen & Jing Gai & Yuqing Xu & Jiawen Mao & Xianming Gao &, 2014. "Evidence That HIV-1 CRF01_AE Is Associated with Low CD4+T Cell Count and CXCR4 Co-Receptor Usage in Recently Infected Young Men Who Have Sex with Men (MSM) in Shanghai, China," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-9, February.
    • Handle: RePEc:plo:pone00:0089462
    DOI: 10.1371/journal.pone.0089462
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    References listed on IDEAS

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    1. Hong-Min Li & Rui-Rui Peng & Jing Li & Yue-Ping Yin & Baoxi Wang & Myron S Cohen & Xiang-Sheng Chen, 2011. "HIV Incidence among Men Who Have Sex with Men in China: A Meta-Analysis of Published Studies," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-8, August.
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