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Review and Analysis of Publication Trends over Three Decades in Three High Impact Medicine Journals

Author

Listed:
  • Alexander Ivanov
  • Beata A Kaczkowska
  • Saadat A Khan
  • Jean Ho
  • Morteza Tavakol
  • Ashok Prasad
  • Geetha Bhumireddy
  • Allan F Beall
  • Igor Klem
  • Parag Mehta
  • William M Briggs
  • Terrence J Sacchi
  • John F Heitner

Abstract

Context: Over the past three decades, industry sponsored research expanded in the United States. Financial incentives can lead to potential conflicts of interest (COI) resulting in underreporting of negative study results. Objective: We hypothesized that over the three decades, there would be an increase in: a) reporting of conflict of interest and source of funding; b) percentage of randomized control trials c) number of patients per study and d) industry funding. Data sources and Study Selection: Original articles published in three calendar years (1988, 1998, and 2008) in The Lancet, New England Journal of Medicine and Journal of American Medical Association were collected. Data Extraction: Studies were reviewed and investigational design categorized as prospective and retrospective clinical trials. Prospective trials were categorized into randomized or non-randomized and single-center or multi-center trials. Retrospective trials were categorized as registries, meta-analyses and other studies, mostly comprising of case reports or series. Study outcomes were categorized as positive or negative depending on whether the pre-specified hypothesis was met. Financial disclosures were researched for financial relationships and profit status, and accordingly categorized as government, non-profit or industry sponsored. Studies were assessed for reporting COI. Results: 1,671 original articles were included in this analysis. Total number of published studies decreased by 17% from 1988 to 2008. Over 20 year period, the proportion of prospective randomized trials increased from 22 to 46% (p

Suggested Citation

  • Alexander Ivanov & Beata A Kaczkowska & Saadat A Khan & Jean Ho & Morteza Tavakol & Ashok Prasad & Geetha Bhumireddy & Allan F Beall & Igor Klem & Parag Mehta & William M Briggs & Terrence J Sacchi & , 2017. "Review and Analysis of Publication Trends over Three Decades in Three High Impact Medicine Journals," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-11, January.
    • Handle: RePEc:plo:pone00:0170056
    DOI: 10.1371/journal.pone.0170056
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    References listed on IDEAS

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    1. Daniele Mandrioli & Cristin E Kearns & Lisa A Bero, 2016. "Relationship between Research Outcomes and Risk of Bias, Study Sponsorship, and Author Financial Conflicts of Interest in Reviews of the Effects of Artificially Sweetened Beverages on Weight Outcomes:," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-20, September.
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    Cited by:

    1. Jiayi Zhu & Ji Sun, 2019. "Conflicts of interest disclosure policies among Chinese medical journals: A cross-sectional study," PLOS ONE, Public Library of Science, vol. 14(7), pages 1-14, July.
    2. Sorana D Bolboacă & Diana-Victoria Buhai & Maria Aluaș & Adriana E Bulboacă, 2019. "Post retraction citations among manuscripts reporting a radiology-imaging diagnostic method," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-14, June.

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