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Relationship between Research Outcomes and Risk of Bias, Study Sponsorship, and Author Financial Conflicts of Interest in Reviews of the Effects of Artificially Sweetened Beverages on Weight Outcomes: A Systematic Review of Reviews

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  • Daniele Mandrioli
  • Cristin E Kearns
  • Lisa A Bero

Abstract

Background: Artificially sweetened beverage consumption has steadily increased in the last 40 years. Several reviews examining the effects of artificially sweetened beverages on weight outcomes have discrepancies in their results and conclusions. Objectives: To determine whether risk of bias, results, and conclusions of reviews of effects of artificially sweetened beverage consumption on weight outcomes differ depending on review sponsorship and authors’ financial conflicts of interest. Methods: We performed a systematic review of reviews of the effects of artificially sweetened beverages on weight. Two assessors independently screened articles for inclusion, extracted data, and assessed risks of bias. We compared risk of bias, results and conclusions of reviews by different industry sponsors, authors’ financial conflict of interest and journal sponsor. We also report the concordance between review results and conclusions. Results: Artificial sweetener industry sponsored reviews were more likely to have favorable results (3/4) than non-industry sponsored reviews (1/23), RR: 17.25 (95% CI: 2.34 to 127.29), as well as favorable conclusions (4/4 vs. 15/23), RR: 1.52 (95% CI: 1.14 to 2.06). All reviews funded by competitor industries reported unfavorable conclusions (4/4). In 42% of the reviews (13/31), authors’ financial conflicts of interest were not disclosed. Reviews performed by authors that had a financial conflict of interest with the food industry (disclosed in the article or not) were more likely to have favorable conclusions (18/22) than reviews performed by authors without conflicts of interest (4/9), RR: 7.36 (95% CI: 1.15 to 47.22). Risk of bias was similar and high in most of the reviews. Conclusions: Review sponsorship and authors’ financial conflicts of interest introduced bias affecting the outcomes of reviews of artificially sweetened beverage effects on weight that could not be explained by other sources of bias.

Suggested Citation

  • Daniele Mandrioli & Cristin E Kearns & Lisa A Bero, 2016. "Relationship between Research Outcomes and Risk of Bias, Study Sponsorship, and Author Financial Conflicts of Interest in Reviews of the Effects of Artificially Sweetened Beverages on Weight Outcomes:," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-20, September.
    • Handle: RePEc:plo:pone00:0162198
    DOI: 10.1371/journal.pone.0162198
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    Cited by:

    1. Damien Wyssa & Martin R Tramèr & Nadia Elia, 2019. "Reporting of conflicts of interest and of sponsorship of guidelines in anaesthesiology. A cross-sectional study," PLOS ONE, Public Library of Science, vol. 14(2), pages 1-13, February.
    2. Béné, Christophe, 2022. "Why the Great Food Transformation may not happen – A deep-dive into our food systems’ political economy, controversies and politics of evidence," World Development, Elsevier, vol. 154(C).
    3. Alexander Ivanov & Beata A Kaczkowska & Saadat A Khan & Jean Ho & Morteza Tavakol & Ashok Prasad & Geetha Bhumireddy & Allan F Beall & Igor Klem & Parag Mehta & William M Briggs & Terrence J Sacchi & , 2017. "Review and Analysis of Publication Trends over Three Decades in Three High Impact Medicine Journals," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-11, January.
    4. Golder, Su & McCambridge, Jim, 2021. "Alcohol, cardiovascular disease and industry funding: A co-authorship network analysis of systematic reviews," Social Science & Medicine, Elsevier, vol. 289(C).
    5. Zhai, Tianchang & Li, Lei & Wang, Jingjing & Si, Wei, 2022. "Will the consumption tax on sugar-sweetened beverages help promote healthy beverage consumption? Evidence from urban China," China Economic Review, Elsevier, vol. 73(C).
    6. Marie A. Bragg & Brian Elbel & Marion Nestle, 2020. "Food Industry Donations to Academic Programs: A Cross-Sectional Examination of the Extent of Publicly Available Data," IJERPH, MDPI, vol. 17(5), pages 1-15, March.
    7. Young Jun Choi & Mi Sun Jeon, 2020. "How Business Interests and Government Inaction Led to the Humidifier Disinfectant Disaster in South Korea: Implications for Better Risk Governance," Risk Analysis, John Wiley & Sons, vol. 40(2), pages 240-253, February.

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