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Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis

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  • Meixiang Zhang
  • Jiawei Xu
  • Xiao Bao
  • Wenbin Niu
  • Linlin Wang
  • Linqing Du
  • Nan Zhang
  • Yingpu Sun

Abstract

Interleukins are a group of immunomodulatory proteins that mediate a variety of immune reactions in the human body. To investigate the association between interleukin gene polymorphisms and recurrent pregnancy loss (RPL), we reviewed 21 studies from MEDLINE, EMBASE, OVID SP and PubMed to evaluate RPL-related interleukin gene polymorphisms. Meta-analysis was performed on 12 of the polymorphisms, and a review included the others. Our integrated results indicated that IL-1β (-511C/T) (P = 0.02, 95% CI 0.77[0.62,0.96]), IL-6 (-634C/G) (P

Suggested Citation

  • Meixiang Zhang & Jiawei Xu & Xiao Bao & Wenbin Niu & Linlin Wang & Linqing Du & Nan Zhang & Yingpu Sun, 2017. "Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-17, January.
    • Handle: RePEc:plo:pone00:0169891
    DOI: 10.1371/journal.pone.0169891
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    Cited by:

    1. Marcello Monti, 2020. "IL-10, HLA-G and Neutrophil Extracellular Traps as Immune Regulators in Recurrent Pregnancy Loss," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 27(1), pages 20516-20518, April.
    2. Kalayu Mekonen Abate & Aamer Nazir & Jeng Ywan Jeng & Kalayu Mekonen Abate & Aamer Nazir & Jeng Ywan Jeng, 2020. "A Short Review on Cellular Structure Design and Selective Laser Melting using Bio-compatible Ti6Al4V Material," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 27(1), pages 20519-20523, April.

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