IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0169650.html
   My bibliography  Save this article

Head Injury as a Risk Factor for Dementia and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of 32 Observational Studies

Author

Listed:
  • Yanjun Li
  • Yongming Li
  • Xiaotao Li
  • Shuang Zhang
  • Jincheng Zhao
  • Xiaofeng Zhu
  • Guozhong Tian

Abstract

Background: Head injury is reported to be associated with increased risks of dementia and Alzheimer’s disease (AD) in many but not all the epidemiological studies. We conducted a systematic review and meta-analysis to estimate the relative effect of head injury on dementia and AD risks. Methods: Relevant cohort and case-control studies published between Jan 1, 1990, and Mar 31, 2015 were searched in PubMed, Web of Science, Scopus, and ScienceDirect. We used the random-effect model in this meta-analysis to take into account heterogeneity among studies. Results: Data from 32 studies, representing 2,013,197 individuals, 13,866 dementia events and 8,166 AD events, were included in the analysis. Overall, the pooled relative risk (RR) estimates showed that head injury significantly increased the risks of any dementia (RR = 1.63, 95% CI 1.34–1.99) and AD (RR = 1.51, 95% CI 1.26–1.80), with no evidence of publication bias. However, when considering the status of unconsciousness, head injury with loss of consciousness did not show significant association with dementia (RR = 0.92, 95% CI 0.67–1.27) and AD (RR = 1.49, 95% CI 0.91–2.43). Additionally, this positive association did not reach statistical significance in female participants. Conclusions: The findings from this meta-analysis indicate that head injury is associated with increased risks of dementia and AD.

Suggested Citation

  • Yanjun Li & Yongming Li & Xiaotao Li & Shuang Zhang & Jincheng Zhao & Xiaofeng Zhu & Guozhong Tian, 2017. "Head Injury as a Risk Factor for Dementia and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of 32 Observational Studies," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-17, January.
  • Handle: RePEc:plo:pone00:0169650
    DOI: 10.1371/journal.pone.0169650
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169650
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169650&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0169650?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Yi-Kung Lee & Sheng-Wen Hou & Ching-Chih Lee & Chen-Yang Hsu & Yung-Sung Huang & Yung-Cheng Su, 2013. "Increased Risk of Dementia in Patients with Mild Traumatic Brain Injury: A Nationwide Cohort Study," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-7, May.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jieyu Zhang & Yongkang Zhang & Juntao Zou & Fei Cao, 2021. "A meta-analysis of cohort studies: Traumatic brain injury and risk of Alzheimer’s Disease," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-8, June.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sheng-Wen Hou & Yi-Kung Lee & Chen-Yang Hsu & Ching-Chih Lee & Yung-Cheng Su, 2013. "Increased Risk of Acute Pancreatitis in Patients with Chronic Hemodialysis: A 4-Year Follow-Up Study," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-6, August.
    2. Shih-Wei Liu & Liang-Chung Huang & Wu-Fu Chung & Hsuan-Kan Chang & Jau-Ching Wu & Li-Fu Chen & Yu-Chun Chen & Wen-Cheng Huang & Henrich Cheng & Su-Shun Lo, 2017. "Increased Risk of Stroke in Patients of Concussion: A Nationwide Cohort Study," IJERPH, MDPI, vol. 14(3), pages 1-12, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0169650. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.